Neurog2 neurogenin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurog2provided by RGD
Official Full Name: neurogenin 2provided by RGD
Primary source: RGD:1309061
See related: EnsemblRapid:ENSRNOG00000010972 AllianceGenome:RGD:1309061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngn2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in nervous system development; regulation of DNA-templated transcription; and sensory organ development. Predicted to act upstream of or within several processes, including cell maturation; generation of neurons; and positive regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human NEUROG2 (neurogenin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (218767205..218769772)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (216092709..216095276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (231962517..231963441)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of miR-211 in a PC12 cell model of Alzheimer's disease via regulation of neurogenin 2.
Title: Role of miR-211 in a PC12 cell model of Alzheimer's disease via regulation of neurogenin 2.
transplantation of neurogenin2-overexpressed adipose-derived stem cells promote the functional recovery from spinal cord injury
Title: Adipose-Derived Stem Cells Expressing the Neurogenin-2 Promote Functional Recovery After Spinal Cord Injury in Rat.
Ngn2 was sufficient to convert MSCs into a neural precursor fate and transplantation of Ngn2-MSCs was advantageous for the treatment of stroke rats.
Title: Neurogenin 2 converts mesenchymal stem cells into a neural precursor fate and improves functional recovery after experimental stroke.
This study demonstrated that Neurogenin 2 enhances the neuronal differentiation of skin-derived precursors.
Title: Neurogenin 2 enhances the neuronal differentiation of skin-derived precursors.
NEUROG2-transduction is sufficient to promote neuronal maturation and integration of transplanted NPCs from SVZ into the DG.
Title: Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus.
The Neuro2 protein expression was barely detected in the mesencephalon of embryos at E11-12, but observed in the ventral domain of E13 midbrain.
Title: Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation.
enhancements in neuronal yield, as well as in donor cell survival, were achieved by transplanting Ngn2-transduced NPCs
Title: Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action.
Subventricular zone neurons can be redirected from their normal migration route and directed towards other brain regions when they are infected with retroviruses encoding the developmentally important transcription factors islet-1 and neurogenin-2.
Title: Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2.
increased GABA neuron yield by Ngn2 and decreased yield by Mash1 were shown in the precursors of posterior brain regions
Title: Contrasting and brain region-specific roles of neurogenin2 and mash1 in GABAergic neuron differentiation in vitro.

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General gene information

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Markers

UniSTS:470670 (e-PCR)
- UniSTS:470670

Neurog2 (e-PCR), detects polymorphism
- UniSTS:470670

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Cajal-Retzius cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398677.1 → NP_001385606.1 neurogenin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HVL7, D4A2E3

Related

ENSRNOP00000105390.1, ENSRNOT00000156070.1

Conserved Domains (1) summary

cd19717
Location:104 → 172

bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins