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    Il10rb interleukin 10 receptor subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304091, updated on 27-Nov-2024

    Summary

    Official Symbol
    Il10rbprovided by RGD
    Official Full Name
    interleukin 10 receptor subunit betaprovided by RGD
    Primary source
    RGD:1560373
    See related
    EnsemblRapid:ENSRNOG00000028638 AllianceGenome:RGD:1560373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560373
    Summary
    Predicted to enable coreceptor activity and interleukin-10 receptor activity. Predicted to be involved in interleukin-10-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 112.5), Lung (RPKM 100.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il10rb in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44132471..44154062)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30646494..30668081)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31560301..31582457)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481055 Neighboring gene uncharacterized LOC120095615 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene uncharacterized LOC120095617 Neighboring gene uncharacterized LOC120095616 Neighboring gene uncharacterized LOC102554317

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-10 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    interleukin 10 receptor, beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107111.1NP_001100581.1  interleukin-10 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_001100581.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      A6JLF1, D3ZM36
      Conserved Domains (2) summary
      pfam09294
      Location:113215
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:23102
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44132471..44154062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270594.1XP_063126664.1  interleukin-10 receptor subunit beta isoform X7

    2. XM_006248062.5XP_006248124.1  interleukin-10 receptor subunit beta isoform X3

      UniProtKB/TrEMBL
      D3ZM36
      Related
      ENSRNOP00000102884.1, ENSRNOT00000147658.1
      Conserved Domains (2) summary
      pfam09294
      Location:113215
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:23102
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_063270593.1XP_063126663.1  interleukin-10 receptor subunit beta isoform X6

    4. XM_063270590.1XP_063126660.1  interleukin-10 receptor subunit beta isoform X1

    5. XM_063270591.1XP_063126661.1  interleukin-10 receptor subunit beta isoform X2

      UniProtKB/TrEMBL
      A6JLF2
      Related
      ENSRNOP00000058062.5, ENSRNOT00000061345.5
    6. XM_006248063.5XP_006248125.1  interleukin-10 receptor subunit beta isoform X4

      UniProtKB/TrEMBL
      D3ZM36
      Related
      ENSRNOP00000110332.1, ENSRNOT00000140116.1
      Conserved Domains (2) summary
      pfam09294
      Location:92194
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:281
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    7. XM_063270592.1XP_063126662.1  interleukin-10 receptor subunit beta isoform X5