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    Cdc42se1 CDC42 small effector 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499672, updated on 27-Nov-2024

    Summary

    Symbol
    Cdc42se1provided by RGD
    Full Name
    CDC42 small effector 1provided by RGD
    Primary source
    RGD:1561700
    See related
    EnsemblRapid:ENSRNOG00000060538 AllianceGenome:RGD:1561700
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in phagocytosis; regulation of Rho protein signal transduction; and regulation of cell shape. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 269.8), Lung (RPKM 247.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdc42se1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185494692..185502519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182805691..182813520)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196402837..196410664)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene GA binding protein transcription factor subunit beta 2 Neighboring gene MLLT11, transcription factor 7 cofactor Neighboring gene similar to human chromosome 1 open reading frame 56 Neighboring gene BCL2 interacting protein like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    CDC42 small effector protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039044.1NP_001034133.1  CDC42 small effector protein 1

      See identical proteins and their annotated locations for NP_001034133.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091418
      UniProtKB/Swiss-Prot
      Q5BJM7
      Related
      ENSRNOP00000099731.1, ENSRNOT00000086849.3
      Conserved Domains (1) summary
      cl00113
      Location:2967
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185494692..185502519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)