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    Dock1 dedicator of cyto-kinesis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309081, updated on 3-Dec-2024

    Summary

    Symbol
    Dock1provided by RGD
    Full Name
    dedicator of cyto-kinesis 1provided by RGD
    Primary source
    RGD:1566072
    See related
    EnsemblRapid:ENSRNOG00000018683 AllianceGenome:RGD:1566072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566072
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including myoblast fusion; positive regulation of substrate adhesion-dependent cell spreading; and regulation of postsynapse assembly. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in several cellular components, including glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 226.5), Kidney (RPKM 222.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dock1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (198897021..199413636)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (189467143..189983777)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (206900617..207414852)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 10 open reading frame 90 Neighboring gene U6 spliceosomal RNA Neighboring gene inhibitory synaptic factor 2A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene Neighboring gene uncharacterized LOC102551753 Neighboring gene neuropeptide S

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 1
    Names
    dedicator of cytokinesis protein 1-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143858.1NP_001137330.1  dedicator of cytokinesis protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HX51
      Conserved Domains (4) summary
      cd08694
      Location:424619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:1368
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72416
      DOCK_N; DOCK N-terminus
      cl06123
      Location:12141612
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      198897021..199413636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263800.1XP_063119870.1  dedicator of cytokinesis protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HX51
      Related
      ENSRNOP00000105953.1, ENSRNOT00000054897.4