Rhobtb1 Rho-related BTB domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rhobtb1provided by RGD
Full Name: Rho-related BTB domain containing 1provided by RGD
Primary source: RGD:1306871
See related: EnsemblRapid:ENSRNOG00000000633 AllianceGenome:RGD:1306871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 163.6), Heart (RPKM 82.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (19326197..19455182, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (19327142..19456121, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (20638579..20715437, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-31a-5p controls postnatal cardiomyocyte proliferation by targeting RhoBTB1, and increasing miR-31a-5p level might be a novel therapeutic strategy for enhancing cardiac reparative processes.
Title: miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Submit: New GeneRIF Correction

General gene information

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Markers

AF045339 (e-PCR)
- UniSTS:138

RH133948 (e-PCR)
- UniSTS:217231

AI173445 (e-PCR)
- UniSTS:159988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107622.2 → NP_001101092.1 rho-related BTB domain-containing protein 1

See identical proteins and their annotated locations for NP_001101092.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Related

ENSRNOP00000000784.6, ENSRNOT00000000784.8

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

19326197..19455182 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098734.2 → XP_038954662.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_063279165.1 → XP_063135235.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37
XM_039098733.2 → XP_038954661.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039098737.2 → XP_038954665.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_063279164.1 → XP_063135234.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37
XM_039098735.2 → XP_038954663.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039098736.2 → XP_038954664.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039098732.2 → XP_038954660.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039098739.2 → XP_038954667.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ATD4, A6JKT8, D3ZD37

Conserved Domains (3) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18530
Location:592 → 691

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:464 → 589

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_039098741.2 → XP_038954669.1 rho-related BTB domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6ATD4

Conserved Domains (3) summary

cd18530
Location:503 → 602

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:375 → 500

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:10 → 118

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039098743.2 → XP_038954671.1 rho-related BTB domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6ATD4

Conserved Domains (3) summary

cd18530
Location:472 → 571

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:344 → 469

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039098740.2 → XP_038954668.1 rho-related BTB domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JWZ1, A0A8I6ATD4

Related

ENSRNOP00000070070.2, ENSRNOT00000087085.3

Conserved Domains (3) summary

cd18530
Location:534 → 633

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cl38908
Location:406 → 531

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:41 → 149

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases