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    Palld palladin, cytoskeletal associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360205, updated on 27-Nov-2024

    Summary

    Symbol
    Palldprovided by RGD
    Full Name
    palladin, cytoskeletal associated proteinprovided by RGD
    Primary source
    RGD:2322545
    See related
    EnsemblRapid:ENSRNOG00000010107 AllianceGenome:RGD:2322545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Palldl1; AABR07025295.1
    Summary
    Enables cytoskeletal protein binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of podosome assembly; and trophoblast giant cell differentiation. Located in several cellular components, including Z disc; actin cytoskeleton; and axonal growth cone. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 195.1), Heart (RPKM 175.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Palld in Genome Data Viewer
    Location:
    16p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33238943..33632236)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28228006..28621349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31865712..31948168)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482494 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC120097508 Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482542 Neighboring gene carbonyl reductase 4 Neighboring gene SH3 domain containing ring finger 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in epithelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within keratinocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ruffle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in trophoblast giant cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    palladin; palladin, cytoskeletal associated protein
    Names
    palladin-like
    palladin-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433250.1NP_001420179.1  palladin, cytoskeletal associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
    2. NM_001433251.1NP_001420180.1  palladin, cytoskeletal associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZQM3
    3. NM_001433252.1NP_001420181.1  palladin, cytoskeletal associated protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A9U3
    4. NM_001433253.1NP_001420182.1  palladin, cytoskeletal associated protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
    5. NM_001433254.1NP_001420183.1  palladin, cytoskeletal associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      33238943..33632236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094916.2XP_038950844.1  palladin isoform X3

      Related
      ENSRNOP00000080820.2, ENSRNOT00000095888.2
      Conserved Domains (6) summary
      pfam07679
      Location:449546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:11611164
      Ig; Ig strand A [structural motif]
      cd05892
      Location:12601351
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:10271118
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:11611251
      Ig; Immunoglobulin domain
    2. XM_039094914.2XP_038950842.1  palladin isoform X1

      Related
      ENSRNOP00000091553.2, ENSRNOT00000111769.2
      Conserved Domains (6) summary
      pfam07679
      Location:449546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:11611164
      Ig; Ig strand A [structural motif]
      cd05892
      Location:12601351
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:10271118
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:11611251
      Ig; Immunoglobulin domain
    3. XM_039094915.2XP_038950843.1  palladin isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADH4
      Conserved Domains (6) summary
      pfam07679
      Location:449546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:11441147
      Ig; Ig strand A [structural motif]
      cd05892
      Location:12431334
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:10101101
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:11441234
      Ig; Immunoglobulin domain
    4. XM_039094917.2XP_038950845.1  palladin isoform X4

      UniProtKB/TrEMBL
      F1M265
      Conserved Domains (5) summary
      pfam07679
      Location:59156
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:771774
      Ig; Ig strand A [structural motif]
      cd05892
      Location:870961
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:637728
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:771861
      Ig; Immunoglobulin domain
    5. XM_008771231.4XP_008769453.1  palladin isoform X5

      Conserved Domains (3) summary
      cd00096
      Location:315384
      Ig; Immunoglobulin domain
      cd05893
      Location:548622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432522
      I-set; Immunoglobulin I-set domain
    6. XM_008771232.4XP_008769454.1  palladin isoform X6

      Related
      ENSRNOP00000088354.1, ENSRNOT00000116705.2
      Conserved Domains (3) summary
      cd00096
      Location:298367
      Ig; Immunoglobulin domain
      cd05893
      Location:531605
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:415505
      I-set; Immunoglobulin I-set domain