Tram1 translocation associated membrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tram1provided by RGD
Official Full Name: translocation associated membrane protein 1provided by RGD
Primary source: RGD:1359100
See related: EnsemblRapid:ENSRNOG00000007892 AllianceGenome:RGD:1359100
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; protein insertion into ER membrane; and response to unfolded protein. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TRAM1 (translocation associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905800.1 and NW_007905801.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
Expression: Biased expression in Liver (RPKM 1086.7), Lung (RPKM 441.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (10425710..10450669)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (5642579..5667666)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (5215196..5297337)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAM1 expression increased in the dorsal root ganglion neurons and dorsal horn neurons after chronic constriction injury.
Title: Translocation Associated Membrane Protein 1 Contributes to Chronic Constriction Injury-Induced Neuropathic Pain in the Dorsal Root Ganglion and Spinal Cord in Rats.
TRAM1 can protect pancreatic inflammation by regulation of necrosis-apoptosis switch in AR42J rat pancreatic acinar cells.
Title: TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134162 (e-PCR)
- UniSTS:217444

RH136958 (e-PCR)
- UniSTS:219047

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in cotranslational protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: translocating chain-associated membrane protein 1

Names: translocating chain-associating membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007701.1 → NP_001007702.1 translocating chain-associated membrane protein 1

See identical proteins and their annotated locations for NP_001007702.1

Status: PROVISIONAL

Source sequence(s)

BC083851

UniProtKB/Swiss-Prot

Q5XI41

UniProtKB/TrEMBL

A0A8L2Q4R9

Related

ENSRNOP00000096261.2, ENSRNOT00000106837.2

Conserved Domains (2) summary

smart00724
Location:117 → 326

TLC; TRAM, LAG1 and CLN8 homology domains

pfam08390
Location:47 → 115

TRAM1; TRAM1-like protein