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    Cct6a chaperonin containing TCP1 subunit 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288620, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cct6aprovided by RGD
    Official Full Name
    chaperonin containing TCP1 subunit 6Aprovided by RGD
    Primary source
    RGD:1304763
    See related
    EnsemblRapid:ENSRNOG00000000923 AllianceGenome:RGD:1304763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable WD40-repeat domain binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in several cellular components, including acrosomal vesicle; cell body; and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT6A (chaperonin containing TCP1 subunit 6A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 226.2), Kidney (RPKM 224.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cct6a in Genome Data Viewer
    Location:
    12q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32508842..32519072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26872736..26883125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30491584..30501813, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene phosphorylase kinase catalytic subunit gamma 1 Neighboring gene uncharacterized LOC120095933 Neighboring gene sulfatase modifying factor 2 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene small nucleolar RNA, H/ACA box 22C Neighboring gene phosphoserine phosphatase Neighboring gene nipsnap homolog 2 Neighboring gene small nucleolar RNA SNORA76

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125121

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables WD40-repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of zona pellucida receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit zeta
    Names
    chaperonin containing Tcp1, subunit 6A (zeta 1)
    chaperonin subunit 6a (zeta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033684.3NP_001028856.1  T-complex protein 1 subunit zeta

      See identical proteins and their annotated locations for NP_001028856.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6ADF8, Q3MHS9
      Related
      ENSRNOP00000083923.2, ENSRNOT00000107709.2
      Conserved Domains (1) summary
      TIGR02347
      Location:3530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32508842..32519072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)