SWI1 Swi1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SWI1
Official Full Name: Swi1p
Primary source: SGD:S000005937
Locus tag: YPL016W
See related: AllianceGenome:SGD:S000005937; FungiDB:YPL016W; VEuPathDB:YPL016W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADR6; GAM3; LPA1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of mating type switching; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of SWI/SNF complex. Orthologous to human ARID5A (AT-rich interaction domain 5A) and ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SWI1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (521014..524958)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction.
Title: Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction.
Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.
Title: Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.
Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses.
Title: Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses.
Structure of the yeast Swi/Snf complex in a nucleosome free state.
Title: Structure of the yeast Swi/Snf complex in a nucleosome free state.
NH2-terminal region of approximately 30 amino acids of Swi1 contains all the necessary information for in vivo prion formation, maintenance, and transmission
Title: Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission.
SWI1 overexpression is a Pin+ factor independent of Rnq1; [SWI+] can facilitate [PSI+] conversion but weaken the Pin+ function of [PIN+]
Title: Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+].
Results provide proof of "protein-only" transmission of [SWI(+)] and demonstrate that the widely distributed "dispensable" glutamine/asparagine-rich regions/motifs might have important and divergent biological functions.
Title: Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function.
integrity of S. cerevisiae Swi/Snf complex is required for invasive and filamentous growth promoted by overexpressing CaSwi1
Title: Functional analysis of ScSwi1 and CaSwi1 in invasive and pseudohyphal growth of Saccharomyces cerevisiae.
Results suggest that the SWI/SNF complex is directly involved in nucleosome removal at HO, and that the histone chaperone Asf1 assists in this during the course of gene regulation.
Title: SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Swi1p

NP_015309.1

Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

521014..524958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183830.2 → NP_015309.1 TPA: Swi1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015309.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3Z6, P09547

UniProtKB/TrEMBL

N1NXD3

Conserved Domains (1) summary

cd16871
Location:407 → 490

ARID_Swi1p-like; ARID/BRIGHT DNA binding domain of yeast SWI/SNF chromatin-remodeling complex subunit Swi1p and similar proteins