NQM1 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NQM1
Official Full Name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1
Primary source: SGD:S000003275
Locus tag: YGR043C
See related: AllianceGenome:SGD:S000003275; FungiDB:YGR043C; VEuPathDB:YGR043C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables transaldolase activity. Involved in cellular response to oxidative stress. Located in nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NQM1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (580435..581436, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Crystal structure of NQM1/YGR043C was determined by the molecular replacement method and refined to a 1.9 A resolution.
Title: The crystal structure and identification of NQM1/YGR043C, a transaldolase from Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables transaldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transaldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables transaldolase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, non-oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1

NP_011557.1

EC 2.2.1.2

Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

580435..581436 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181172.1 → NP_011557.1 TPA: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011557.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUI1, P53228, Q6Q5P8

UniProtKB/TrEMBL

A6ZV31, B3LIH8, B5VIZ6, C7GXM9, C8Z8T9, E9P9A0, G2WED3, N1P3G9

Conserved Domains (1) summary

TIGR00874
Location:14 → 333

talAB; transaldolase