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    HEM4 uroporphyrinogen-III synthase HEM4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HEM4
    Official Full Name
    uroporphyrinogen-III synthase HEM4
    Primary source
    SGD:S000005804
    Locus tag
    YOR278W
    See related
    AllianceGenome:SGD:S000005804; FungiDB:YOR278W; VEuPathDB:YOR278W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLU2
    Summary
    Enables uroporphyrinogen-III synthase activity. Involved in heme biosynthetic process. Predicted to be active in cytosol. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HEM4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (842817..843644)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rfm1p Neighboring gene putative serine hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a nuclear yeast gene involved in the mitochondrial import of cytoplasmically synthesized precursor proteins. Langgut W, et al. Curr Genet, 1986. PMID 2834088
    2. Genetic analysis of a respiration-deficient mutant of Saccharomyces cerevisiae lacking all cytochromes and accumulating coproporphyrin. Gunge N, et al. Genetics, 1967 Oct. PMID 5584564, Free PMC Article
    3. A respiration-deficient mutant of Saccharomyces cerevisiae which accumulates porphyrins and lacks cytochromes. Sugimura T, et al. Biochim Biophys Acta, 1966 Feb 28. PMID 5943431
    4. Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Tan FC, et al. Biochem J, 2008 Mar 1. PMID 18042043
    5. A rAAV2-producing yeast screening model to identify host proteins enhancing rAAV DNA replication and vector yield. Aponte-Ubillus JJ, et al. Biotechnol Prog, 2019 Jan. PMID 30298993

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen-III synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen-III synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables uroporphyrinogen-III synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase HEM4
    NP_014921.1
    • Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      842817..843644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183697.1 → NP_014921.1  TPA: uroporphyrinogen-III synthase HEM4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014921.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X7, P06174
      UniProtKB/TrEMBL
      A6ZPB4, B3LJU3, B5VSF8, C7GWB3, C8ZH28, G2WNE5, N1NYU0
      Conserved Domains (1) summary
      pfam02602
      Location:26 → 266
      HEM4; Uroporphyrinogen-III synthase HemD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06174.2

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