Arhgap17 Rho GTPase activating protein 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap17provided by RGD
Official Full Name: Rho GTPase activating protein 17provided by RGD
Primary source: RGD:628767
See related: EnsemblRapid:ENSRNOG00000013836 AllianceGenome:RGD:628767
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rich1
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in cytoplasm. Biomarker of acute myocardial infarction. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 158.2), Spleen (RPKM 154.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (187238675..187328093, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (177807579..177897027, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (193239036..193328425, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium-ion regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 17

Names: neuron-associated developmentally-regulated protein; neuron-specific GTPase-activating protein; rho-type GTPase-activating protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270692.1 → NP_001257621.1 rho GTPase-activating protein 17 isoform 1

See identical proteins and their annotated locations for NP_001257621.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB042827, BC085736

UniProtKB/Swiss-Prot

Q8R506, Q99N37, Q99N38, Q9EQV7

UniProtKB/TrEMBL

F1M6X7

Related

ENSRNOP00000038504.7, ENSRNOT00000031770.9

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001270693.1 → NP_001257622.1 rho GTPase-activating protein 17 isoform 3

See identical proteins and their annotated locations for NP_001257622.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AB042827, BC085736, JAXUCZ010000001

UniProtKB/TrEMBL

D4AAV4

Related

ENSRNOP00000019309.8, ENSRNOT00000019309.10

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001270694.1 → NP_001257623.1 rho GTPase-activating protein 17 isoform 4

See identical proteins and their annotated locations for NP_001257623.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AB042827, BC085736, JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ALM5

Related

ENSRNOP00000019305.9, ENSRNOT00000019304.9

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_022244.2 → NP_071580.1 rho GTPase-activating protein 17 isoform 2

See identical proteins and their annotated locations for NP_071580.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB042827, BC085736

UniProtKB/TrEMBL

A6I8Z6

Related

ENSRNOP00000076440.2, ENSRNOT00000097528.2

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

187238675..187328093 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089209.2 → XP_038945137.1 rho GTPase-activating protein 17 isoform X1

UniProtKB/TrEMBL

F1M6X7

Related

ENSRNOP00000080152.2, ENSRNOT00000105291.2

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
XM_039089216.2 → XP_038945144.1 rho GTPase-activating protein 17 isoform X4

UniProtKB/TrEMBL

A6I8Z6

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
XM_039089217.2 → XP_038945145.1 rho GTPase-activating protein 17 isoform X6

Conserved Domains (1) summary

cd04386
Location:1 → 173

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
XM_006230194.5 → XP_006230256.2 rho GTPase-activating protein 17 isoform X3

UniProtKB/TrEMBL

A0A8I5Y535, A0A8I5ZP42

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
XM_063272630.1 → XP_063128700.1 rho GTPase-activating protein 17 isoform X2
XM_063272639.1 → XP_063128709.1 rho GTPase-activating protein 17 isoform X5