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    Ip6k1 inositol hexaphosphate kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 27399, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Ip6k1provided by MGI
    Official Full Name
    inositol hexaphosphate kinase 1provided by MGI
    Primary source
    MGI:MGI:1351633
    See related
    Ensembl:ENSMUSG00000032594 AllianceGenome:MGI:1351633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ihpk1; InsP6; Itpk6; InsP6k1; 1200016D08Rik
    Summary
    Predicted to enable inositol hexakisphosphate kinase activity. Involved in negative regulation of cold-induced thermogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 61.4), ovary adult (RPKM 49.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ip6k1 in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107879847..107925981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108002648..108048782)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene inka box actin regulator 1 Neighboring gene RIKEN cDNA 4930535L15 gene Neighboring gene cadherin-related family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene STARR-positive B cell enhancer ABC_E2305 Neighboring gene STARR-positive B cell enhancer ABC_E6803 Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution. Boregowda SV, et al. Stem Cells, 2017 Aug. PMID 28577302, Free PMC Article
    2. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Prasad A, et al. Nat Immunol, 2011 Jun 19. PMID 21685907, Free PMC Article
    3. Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Chakraborty A, et al. Cell, 2010 Dec 10. PMID 21145457, Free PMC Article
    4. Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair. Jadav RS, et al. J Biol Chem, 2013 Feb 1. PMID 23255604, Free PMC Article
    5. Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability. Jin H, et al. Mol Brain, 2024 Feb 13. PMID 38350944, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
      Title: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
    2. Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
      Title: Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
    3. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
      Title: Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
    4. Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
      Title: Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
    5. Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
      Title: Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
    6. Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
      Title: Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
    7. the unique metabolic sensing properties of IP6K1 guarantees appropriate concentrations of IP7 and thereby both correct basal insulin secretion and intact first phase insulin release.
      Title: Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
    8. juvenile spermatids from Ip6k1(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression.
      Title: IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
    9. these findings reveal an important role for IP6K1 in regulating Mesenchymal stem/stromal cell fitness and differentiation fate.
      Title: IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
    10. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate.
      Title: Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Cdhr4

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol hexakisphosphate kinase 1
    Names
    inositol hexakisphosphate kinase 6
    insP6 kinase 1
    NP_038813.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013785.2 → NP_038813.2  inositol hexakisphosphate kinase 1

      See identical proteins and their annotated locations for NP_038813.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059006
      Consensus CDS
      CCDS23514.1
      UniProtKB/Swiss-Prot
      Q6PD10, Q9QXV6
      UniProtKB/TrEMBL
      Q6A097
      Related
      ENSMUSP00000035214.5, ENSMUST00000035214.11
      Conserved Domains (1) summary
      pfam03770
      Location:207 → 426
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107879847..107925981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026266.1: Suppressed sequence

      Description
      NM_026266.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PD10.1 GenPept UniProtKB/Swiss-Prot:Q6PD10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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