Or2c1 olfactory receptor family 2 subfamily C member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or2c1provided by MGI
Official Full Name: olfactory receptor family 2 subfamily C member 1provided by MGI
Primary source: MGI:MGI:106182
See related: Ensembl:ENSMUSG00000059043 AllianceGenome:MGI:106182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OR3; Olfr15; MOR256-17
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.26 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (3656839..3657777)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (3838975..3839913)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that Olfr15 and Olfr821 in pancreatic beta-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism.
Title: Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion.
In islets from type 2 diabetic mice, the expression level of Olfr15 and the octanoic acid-induced enhancement of glucose-stimulated insulin secretion were strongly reduced.
Title: Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells.
homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71, supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons.
Title: Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor.
we have performed a detailed examination the mouse odorant receptor MOR256-17, demonstrating that this receptor is broadly tuned
Title: A broadly tuned mouse odorant receptor that detects nitrotoluenes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489093

Olfr15 (e-PCR), detects polymorphism
- UniSTS:526061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactory receptor 2C1

Names: GA_x54KRFPKG5P-348087-349025; odorant receptor OR3; olfactory receptor 15; olfactory receptor 256-17; olfactory receptor MOR256-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008762.2 → NP_032788.2 olfactory receptor 2C1

See identical proteins and their annotated locations for NP_032788.2

Status: VALIDATED

Source sequence(s)

AC129021

Consensus CDS

CCDS27910.1

UniProtKB/Swiss-Prot

P23275, Q496W6, Q8VFF0

UniProtKB/TrEMBL

Q496X2

Related

ENSMUSP00000079720.2, ENSMUST00000080917.2

Conserved Domains (2) summary

pfam00001
Location:41 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:35 → 305

7tm_4; Olfactory receptor