C1ql3 C1q-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1ql3provided by MGI
Official Full Name: C1q-like 3provided by MGI
Primary source: MGI:MGI:2387350
See related: Ensembl:ENSMUSG00000049630 AllianceGenome:MGI:2387350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adij; C1ql; K100; CTRP13; C1qtnf13; 1110065A22Rik
Summary: Enables identical protein binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic density assembly. Acts upstream of or within regulation of synapse organization. Located in extracellular region. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. Is expressed in several structures, including adipose tissue; brain; cranial ganglion; genitourinary system; and hemolymphoid system. Orthologous to human C1QL3 (complement C1q like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 21.1), cortex adult (RPKM 17.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 9.68 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (13006591..13016491, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (13001887..13010864, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTRP13 ablation improves systemic glucose and lipid metabolism.
Title: CTRP13 ablation improves systemic glucose and lipid metabolism.
A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of beta-cell function.
Title: A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function.
miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3.
Title: miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3.
CTRP13 preserves endothelial function in diabetic mice by regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the therapeutic potential of CTRP13 against diabetic vasculopathy.
Title: CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes.
Data identify C1QL3 as a signaling molecule that is highly expressed in suprachiasmatic nucleus neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.
Title: Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus.
results suggest that C1ql3 is a signaling protein essential for subsets of synaptic projections and the behaviors controlled by these projections.
Title: Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors.
CTRP13 and AgRP form a hypothalamic feedback loop to modulate food intake
Title: A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight.
CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase.
Title: Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

C1ql3 (e-PCR), detects polymorphism
- UniSTS:531288

C1ql3 (e-PCR), detects polymorphism
- UniSTS:531053

AI661623 (e-PCR)
- UniSTS:185463

AA893351 (e-PCR)
- UniSTS:243376

BB099929 (e-PCR)
- UniSTS:207287

C1ql3 (e-PCR), detects polymorphism
- UniSTS:547562

C1ql3 (e-PCR), detects polymorphism
- UniSTS:547563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: complement C1q-like protein 3

Names: C1q and tumor necrosis factor-related protein 13; C1q/TNF-related protein 13; adiponectin j; gliacolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.