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    Muc16 mucin 16 [ Mus musculus (house mouse) ]

    Gene ID: 73732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Muc16provided by MGI
    Official Full Name
    mucin 16provided by MGI
    Primary source
    MGI:MGI:1920982
    See related
    Ensembl:ENSMUSG00000109564 AllianceGenome:MGI:1920982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca125; Gm1480; Gm21044; 1110008I14Rik
    Summary
    Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Muc16 in Genome Data Viewer
    Location:
    9 A2; 9 7.06 cM
    Exon count:
    89
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (18406741..18586117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (18495445..18674821, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23418 Neighboring gene STARR-seq mESC enhancer starr_23419 Neighboring gene zinc finger protein 558 Neighboring gene STARR-seq mESC enhancer starr_23420 Neighboring gene methyl-CpG binding domain protein 3-like 1 Neighboring gene predicted gene, 39297 Neighboring gene predicted gene, 24546 Neighboring gene STARR-seq mESC enhancer starr_23423 Neighboring gene olfactory receptor family 1 subfamily M member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CA125/MUC16 is dispensable for mouse development and reproduction. Cheon DJ, et al. PLoS One, 2009. PMID 19262696, Free PMC Article
    2. Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125. Shojaeian S, et al. Iran J Immunol, 2009 Dec. PMID 20054105
    3. Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail. Giannakouros P, et al. Int J Oncol, 2015 Jan. PMID 25338620
    4. Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). Maeda T, et al. J Biol Chem, 2004 Mar 26. PMID 14764598
    5. MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse. Wang Y, et al. Differentiation, 2008 Dec. PMID 18637025, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
      Title: Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
    2. Authors confirm that MUC16 inhibits cytolysis by human NK cells as well as the formation of NK-tumor conjugates. Mice implanted with MUC16-knockdown OVCAR-3 show >2-fold increase in survival compared to controls. Murine NK cells and macrophages are more efficient at lysing MUC16-knockdown cells.
      Title: MUC16 suppresses human and murine innate immune responses.
    3. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
      Title: Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
    4. MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
      Title: Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16.
    5. MUC16 functions as an oncogene. The cytoplasmic tail is critical for MUC16 oncogenic properties.
      Title: Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail.
    6. Data show that intraperitoneal injections of living CA 125 positive cells of OVCAR-3 cell line, and boosted by intravenous injection of the purified extracellular domain of CA 125 was found to have excellent immunoreactivity for CA 125 mAb production.
      Title: Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125.
    7. Lack of any prominent abnormal phenotype in Muc16 knockout mice suggests that CA125/MUC16 is not required for normal development or reproduction
      Title: CA125/MUC16 is dispensable for mouse development and reproduction.
    8. the presence of MUC16 in murine ovarian cancer and in normal tissues
      Title: MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mucin-16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378248.1 → NP_001365177.1  mucin-16 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154519, AC154784, AC162941
      UniProtKB/TrEMBL
      A0A140LJ72
      Conserved Domains (4) summary
      pfam05109
      Location:4987 → 5361
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01390
      Location:8618 → 8725
      SEA; SEA domain
      NF033849
      Location:4828 → 5122
      ser_rich_anae_1; serine-rich protein
      cl41733
      Location:8748 → 8782
      Syt1_2_N; N-terminal domain of synaptotagmin-1 and -2

    2. NM_001428752.1 → NP_001415681.1  mucin-16 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154519, AC154784, AC162941
      UniProtKB/TrEMBL
      A0A140LJ72

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      18406741..18586117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242634.1 → XP_011240936.1  mucin-16 isoform X1

      Related
      ENSMUSP00000147104.2, ENSMUST00000208663.2
      Conserved Domains (2) summary
      pfam05109
      Location:4987 → 5361
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01390
      Location:6180 → 6281
      SEA; SEA domain

    2. XM_011242636.1 → XP_011240938.1  mucin-16 isoform X2

      See identical proteins and their annotated locations for XP_011240938.1

      UniProtKB/TrEMBL
      A0A140LJ72
      Conserved Domains (3) summary
      pfam05109
      Location:4962 → 5336
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01390
      Location:6155 → 6256
      SEA; SEA domain
      pfam16038
      Location:8734 → 8788
      TMIE; TMIE protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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    Research Materials