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    Nkain1 Na+/K+ transporting ATPase interacting 1 [ Mus musculus (house mouse) ]

    Gene ID: 67149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkain1provided by MGI
    Official Full Name
    Na+/K+ transporting ATPase interacting 1provided by MGI
    Primary source
    MGI:MGI:1914399
    See related
    Ensembl:ENSMUSG00000078532 AllianceGenome:MGI:1914399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610200G18Rik; 2810426C15Rik
    Summary
    Enables ATPase binding activity. Predicted to be involved in regulation of sodium ion transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; lung; metanephros; and retina layer. Orthologous to human NKAIN1 (sodium/potassium transporting ATPase interacting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 62.7), CNS E18 (RPKM 54.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkain1 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130297176..130341115)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130530131..130574216, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074 Neighboring gene STARR-positive B cell enhancer ABC_E425 Neighboring gene small nuclear ribonucleoprotein 40 (U5) Neighboring gene STARR-seq mESC enhancer starr_11526 Neighboring gene STARR-seq mESC enhancer starr_11530 Neighboring gene predicted gene, 53228 Neighboring gene STARR-seq mESC enhancer starr_11531 Neighboring gene STARR-seq mESC enhancer starr_11533 Neighboring gene pumilio RNA-binding family member 1 Neighboring gene small nucleolar RNA, C/D box 85

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144417

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
    Names
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427131.1 → NP_001414060.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      FO907130, FQ976844, MH423692

    2. NM_001427132.1 → NP_001414061.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      FO907130, FQ976844, MH423692

    3. NM_001427133.1 → NP_001414062.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      FO907130, FQ976844, MH423692

    4. NM_001427134.1 → NP_001414063.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      FO907130, FQ976844, MH423692

    5. NM_025998.5 → NP_080274.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080274.2

      Status: VALIDATED

      Source sequence(s)
      FO907130, FQ976844, MH423692
      Consensus CDS
      CCDS57302.1
      UniProtKB/Swiss-Prot
      A6MHP4, Q9D035, Q9D0Q6
      Related
      ENSMUSP00000101614.3, ENSMUST00000105993.4
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 206
      NKAIN; Na,K-Atpase Interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130297176..130341115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164361.1 → XP_036020254.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X4

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 110
      NKAIN; Na,K-Atpase Interacting protein

    2. XM_006539117.5 → XP_006539180.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      pfam05640
      Location:26 → 210
      NKAIN; Na,K-Atpase Interacting protein

    3. XM_006539116.5 → XP_006539179.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X1

      Conserved Domains (1) summary
      pfam05640
      Location:26 → 213
      NKAIN; Na,K-Atpase Interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D035.2 GenPept UniProtKB/Swiss-Prot:Q9D035

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