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    Nt5dc3 5'-nucleotidase domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 103466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5dc3provided by MGI
    Official Full Name
    5'-nucleotidase domain containing 3provided by MGI
    Primary source
    MGI:MGI:3513266
    See related
    Ensembl:ENSMUSG00000054027 Ensembl:ENSMUSG00000112743 AllianceGenome:MGI:3513266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TU12B1-TY; C630002B14Rik
    Summary
    Predicted to enable 5'-nucleotidase activity. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and lung. Orthologous to human NT5DC3 (5'-nucleotidase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.7), adrenal adult (RPKM 14.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nt5dc3 in Genome Data Viewer
    Location:
    10 C1; 10 43.11 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86614857..86674253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86778992..86838389)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, beta (Grp94), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene STARR-positive B cell enhancer ABC_E8356 Neighboring gene STARR-seq mESC enhancer starr_27475 Neighboring gene stabilin 2 Neighboring gene ADNP homeobox 2 pseudogene Neighboring gene predicted gene 16271 Neighboring gene predicted gene, 53582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia. van den Akker E, et al. J Virol, 2005 May. PMID 15827139, Free PMC Article
    2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    3. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5'-nucleotidase domain-containing protein 3
    Names
    TU12B1-TY protein homolog
    NP_780540.2
    XP_036011377.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175331.3 → NP_780540.2  5'-nucleotidase domain-containing protein 3

      See identical proteins and their annotated locations for NP_780540.2

      Status: VALIDATED

      Source sequence(s)
      AK147488, CJ098720, CJ256052
      Consensus CDS
      CCDS36020.1
      UniProtKB/Swiss-Prot
      Q3T9W5, Q3UHB1
      Related
      ENSMUSP00000096994.3, ENSMUST00000099396.3
      Conserved Domains (1) summary
      pfam05761
      Location:91 → 524
      5_nucleotid; 5' nucleotidase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      86614857..86674253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155484.1 → XP_036011377.1  5'-nucleotidase domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2P799
      Related
      ENSMUSP00000151537.2, ENSMUST00000218802.2
      Conserved Domains (1) summary
      pfam05761
      Location:18 → 451
      5_nucleotid; 5' nucleotidase family

    RNA

    1. XR_003948574.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHB1.1 GenPept UniProtKB/Swiss-Prot:Q3UHB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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