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    Ccn6 cellular communication network factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 327743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccn6provided by MGI
    Official Full Name
    cellular communication network factor 6provided by MGI
    Primary source
    MGI:MGI:2685581
    See related
    Ensembl:ENSMUSG00000062074 AllianceGenome:MGI:2685581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm735; Wisp3; WISP-3
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in extracellular matrix and extracellular space. Is expressed in embryo. Used to study breast metaplastic carcinoma and progressive pseudorheumatoid arthropathy of childhood. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 4.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccn6 in Genome Data Viewer
    Location:
    10 B1; 10 20.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39026966..39049484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39150970..39174376, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene laminin, alpha 4 Neighboring gene STARR-seq mESC enhancer starr_26379 Neighboring gene STARR-seq mESC enhancer starr_26383 Neighboring gene family with sequence similarity 229, member B Neighboring gene STARR-seq mESC enhancer starr_26384 Neighboring gene tubulin, epsilon 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:38891010-38891195 Neighboring gene STARR-positive B cell enhancer ABC_E3883 Neighboring gene STARR-positive B cell enhancer ABC_E1797 Neighboring gene STARR-seq mESC enhancer starr_26386 Neighboring gene STARR-seq mESC enhancer starr_26387 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 31562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Martin EE, et al. Oncogene, 2017 Apr 20. PMID 27819674, Free PMC Article
    2. Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse. Lester WC, et al. Biol Reprod, 2021 Dec 20. PMID 34518881, Free PMC Article
    3. WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells. Wei S, et al. Gene, 2018 Oct 5. PMID 29920361
    4. A Wisp3 Cre-knockin allele produces efficient recombination in spermatocytes during early prophase of meiosis I. Hann S, et al. PLoS One, 2013. PMID 24040393, Free PMC Article
    5. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Kutz WE, et al. Mol Cell Biol, 2005 Jan. PMID 15601861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells
      Title: WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells.
    2. demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397).
      Title: CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway.
    3. the WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice [WISP3]
      Title: WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cellular communication network factor 6
    Names
    CCN family member 6
    WNT1 inducible signaling pathway protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127376.1 → NP_001120848.1  cellular communication network factor 6 precursor

      See identical proteins and their annotated locations for NP_001120848.1

      Status: VALIDATED

      Source sequence(s)
      AC153958
      Consensus CDS
      CCDS48537.1
      UniProtKB/Swiss-Prot
      D3Z5L9
      Related
      ENSMUSP00000076003.5, ENSMUST00000076713.6
      Conserved Domains (3) summary
      pfam00219
      Location:48 → 100
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:209 → 252
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:275 → 341
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39026966..39049484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155821.1 → XP_036011714.1  cellular communication network factor 6 isoform X1

      UniProtKB/Swiss-Prot
      D3Z5L9
      Conserved Domains (3) summary
      pfam00219
      Location:48 → 100
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:209 → 252
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:275 → 341
      GHB_like; Glycoprotein hormone beta chain homologues

    2. XM_030245127.2 → XP_030100987.1  cellular communication network factor 6 isoform X1

      UniProtKB/Swiss-Prot
      D3Z5L9
      Conserved Domains (3) summary
      pfam00219
      Location:48 → 100
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:209 → 252
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:275 → 341
      GHB_like; Glycoprotein hormone beta chain homologues

    3. XM_036155822.1 → XP_036011715.1  cellular communication network factor 6 isoform X1

      UniProtKB/Swiss-Prot
      D3Z5L9
      Conserved Domains (3) summary
      pfam00219
      Location:48 → 100
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:209 → 252
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:275 → 341
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z5L9.2 GenPept UniProtKB/Swiss-Prot:D3Z5L9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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