Steap1 six transmembrane epithelial antigen of the prostate 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Steap1provided by MGI
Official Full Name: six transmembrane epithelial antigen of the prostate 1provided by MGI
Primary source: MGI:MGI:1917608
See related: Ensembl:ENSMUSG00000015652 AllianceGenome:MGI:1917608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Steap; Prss24; 2410007B19Rik
Summary: Predicted to enable heme binding activity. Located in endosome and plasma membrane. Is expressed in central nervous system and retina. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 2.8), placenta adult (RPKM 2.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.2 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (5786322..5799317, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (5736322..5749317, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
Title: Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
HSP65 and STEAP1 186-193 can significantly inhibit the growth of mouse RM-1 prostate cancer.
Title: Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 (186-193).
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Steap (e-PCR), detects polymorphism
- UniSTS:231356

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables cupric reductase (NADH) activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables ferric-chelate reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within copper ion import	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within iron ion import across cell outer membrane	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STEAP1 protein

Names: metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1

NP_081675.2

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.