Gpr155 G protein-coupled receptor 155 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr155provided by MGI
Official Full Name: G protein-coupled receptor 155provided by MGI
Primary source: MGI:MGI:1915776
See related: Ensembl:ENSMUSG00000041762 AllianceGenome:MGI:1915776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGR22; DEPDC3; LYCHOS; 1110017O10Rik; F730029F15Rik
Summary: Predicted to enable cholesterol binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and regulation of signal transduction. Predicted to be active in lysosomal membrane. Is expressed in several structures, including brain; genitourinary system; liver; spinal cord; and spleen. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 5.0), genital fat pad adult (RPKM 4.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 43.59 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (73171850..73216842, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (73341506..73386521, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
Title: Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.
This study reports the structural organization of mouse GPR155 gene and the generation of five variants (Variants 1-5) of GPR155 mRNA, including so far unknown four variants.
Title: GPR155: Gene organization, multiple mRNA splice variants and expression in mouse central nervous system.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

07.MMHAP16FRC7.seq (e-PCR)
- UniSTS:158973

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cholesterol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysosomal cholesterol signaling protein

Names: integral membrane protein GPR155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190297.2 → NP_001177226.1 lysosomal cholesterol signaling protein isoform 1

See identical proteins and their annotated locations for NP_001177226.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL954713, AV115983, HM161763

Consensus CDS

CCDS50606.1

UniProtKB/Swiss-Prot

A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2

Related

ENSMUSP00000075788.6, ENSMUST00000076463.12

Conserved Domains (2) summary

cd04443
Location:749 → 831

DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...

cl22894
Location:36 → 364

Mem_trans; Membrane transport protein
NM_001276443.1 → NP_001263372.1 lysosomal cholesterol signaling protein isoform 3

See identical proteins and their annotated locations for NP_001263372.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL954713, AV115983, HM161764

UniProtKB/TrEMBL

D7RXL9

Conserved Domains (2) summary

cl02442
Location:749 → 776

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

cl22894
Location:36 → 364

Mem_trans; Membrane transport protein
NM_001276444.1 → NP_001263373.1 lysosomal cholesterol signaling protein isoform 4

See identical proteins and their annotated locations for NP_001263373.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.

Source sequence(s)

AL954713, AV115983, HM161766

Consensus CDS

CCDS71075.1

UniProtKB/TrEMBL

A2AWR2

Related

ENSMUSP00000107675.2, ENSMUST00000112044.8

Conserved Domains (2) summary

cd04443
Location:721 → 803

DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...

cl22894
Location:36 → 364

Mem_trans; Membrane transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

73171850..73216842 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500106.3 → XP_006500169.1 lysosomal cholesterol signaling protein isoform X2

See identical proteins and their annotated locations for XP_006500169.1

UniProtKB/Swiss-Prot

A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2

Conserved Domains (2) summary

cd04443
Location:749 → 831

DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...

cl22894
Location:36 → 364

Mem_trans; Membrane transport protein
XM_006500104.3 → XP_006500167.1 lysosomal cholesterol signaling protein isoform X1

See identical proteins and their annotated locations for XP_006500167.1

Conserved Domains (2) summary

cd04443
Location:762 → 844

DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...

cl22894
Location:49 → 377

Mem_trans; Membrane transport protein
XM_006500105.3 → XP_006500168.1 lysosomal cholesterol signaling protein isoform X1

See identical proteins and their annotated locations for XP_006500168.1

Conserved Domains (2) summary

cd04443
Location:762 → 844

DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...

cl22894
Location:49 → 377

Mem_trans; Membrane transport protein
XM_006500107.4 → XP_006500170.1 lysosomal cholesterol signaling protein isoform X3

Related

ENSMUST00000048504.10

Conserved Domains (2) summary

cl22894
Location:49 → 377

Mem_trans; Membrane transport protein

cl02442
Location:762 → 789

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
XM_006500108.5 → XP_006500171.1 lysosomal cholesterol signaling protein isoform X4

Conserved Domains (2) summary

cl22894
Location:49 → 377

Mem_trans; Membrane transport protein

cl02442
Location:762 → 790

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001080707.1: Suppressed sequence

Description

NM_001080707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.