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    Adgrd1 adhesion G protein-coupled receptor D1 [ Mus musculus (house mouse) ]

    Gene ID: 243277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrd1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor D1provided by MGI
    Primary source
    MGI:MGI:3041203
    See related
    Ensembl:ENSMUSG00000044017 AllianceGenome:MGI:3041203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr133; E230012M21Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nuclear speck. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; foregut; hypothalamus; skeleton; and white fat. Orthologous to human ADGRD1 (adhesion G protein-coupled receptor D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 23.4), mammary gland adult (RPKM 10.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrd1 in Genome Data Viewer
    Location:
    5 G1.3; 5 67.99 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129173741..129281663)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129096750..129204599)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14429 Neighboring gene syntaxin 2 Neighboring gene RAN, member RAS oncogene family Neighboring gene predicted gene, 52830 Neighboring gene predicted gene, 46923 Neighboring gene ribosomal protein S16, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_14430 Neighboring gene STARR-seq mESC enhancer starr_14432 Neighboring gene STARR-seq mESC enhancer starr_14435 Neighboring gene STARR-seq mESC enhancer starr_14441 Neighboring gene STARR-seq mESC enhancer starr_14443 Neighboring gene predicted gene, 34145 Neighboring gene STARR-seq mESC enhancer starr_14450 Neighboring gene predicted gene, 54304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Bianchi E, et al. Nat Commun, 2021 Feb 23. PMID 33623007, Free PMC Article
    2. Cell adhesion receptor GPR133 couples to Gs protein. Bohnekamp J, et al. J Biol Chem, 2011 Dec 9. PMID 22025619, Free PMC Article
    3. The period of the somite segmentation clock is sensitive to Notch activity. Kim W, et al. Mol Biol Cell, 2011 Sep. PMID 21795391, Free PMC Article
    4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.
      Title: Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.
    2. Cell adhesion receptor GPR133 couples to Gs protein
      Title: Cell adhesion receptor GPR133 couples to Gs protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor D1
    Names
    G protein coupled receptor Gpr133
    G-protein coupled receptor PGR25
    probable G-protein coupled receptor 133

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081342.1 → NP_001074811.1  adhesion G-protein coupled receptor D1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001074811.1

      Status: VALIDATED

      Source sequence(s)
      AC115899, AC158913
      Consensus CDS
      CCDS39289.1
      UniProtKB/Swiss-Prot
      B2RXC3, Q80T32, Q8BW80
      Related
      ENSMUSP00000060307.8, ENSMUST00000056617.14
      Conserved Domains (3) summary
      pfam01825
      Location:539 → 579
      GPS; GPCR proteolysis site, GPS, motif
      pfam13385
      Location:173 → 273
      Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
      cl21561
      Location:595 → 831
      7tm_4; Olfactory receptor

    2. NM_001347486.1 → NP_001334415.1  adhesion G-protein coupled receptor D1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC115899, AC158913
      Consensus CDS
      CCDS84966.1
      UniProtKB/TrEMBL
      B2RXV6
      Related
      ENSMUSP00000121217.3, ENSMUST00000156437.3
      Conserved Domains (4) summary
      smart00303
      Location:505 → 552
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam13385
      Location:167 → 241
      Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
      cd14964
      Location:562 → 587
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:560 → 819
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129173741..129281663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165131.1 → XP_036021024.1  adhesion G-protein coupled receptor D1 isoform X1

      Conserved Domains (4) summary
      smart00303
      Location:477 → 524
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam13385
      Location:139 → 213
      Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
      cd14964
      Location:534 → 559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:532 → 791
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006504308.3 → XP_006504371.1  adhesion G-protein coupled receptor D1 isoform X2

      Conserved Domains (3) summary
      smart00303
      Location:264 → 311
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:321 → 346
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:319 → 578
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177734.2: Suppressed sequence

      Description
      NM_177734.2: This RefSeq was removed because it is thought to be a partial transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T32.2 GenPept UniProtKB/Swiss-Prot:Q80T32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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