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    Glrx2 glutaredoxin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114022, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Glrx2provided by RGD
    Official Full Name
    glutaredoxin 2provided by RGD
    Primary source
    RGD:1307950
    See related
    EnsemblRapid:ENSRNOG00000003385 AllianceGenome:RGD:1307950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-disulfide reductase activity. Involved in cellular response to superoxide. Located in dendrite; mitochondrial matrix; and neuronal cell body. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 144.7), Brain (RPKM 127.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glrx2 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (58032199..58055061)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (55481875..55504737)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (60529057..60552115)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 73 Neighboring gene Beta-1,3-galactosyltransferase 2 Neighboring gene uncharacterized LOC108352545 Neighboring gene Ro60, Y RNA binding protein Neighboring gene uncharacterized LOC120096268 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene ubiquitin C-terminal hydrolase L5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation. Gao XH, et al. Redox Biol, 2013. PMID 25126518, Free PMC Article
    2. Identification of potential protein dithiol-disulfide substrates of mammalian Grx2. Schütte LD, et al. Biochim Biophys Acta, 2013 Nov. PMID 23872354
    3. What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Pai HV, et al. Antioxid Redox Signal, 2007 Nov. PMID 17845131
    4. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. Gladyshev VN, et al. J Biol Chem, 2001 Aug 10. PMID 11397793
    5. Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia. Romero JI, et al. Biochim Biophys Acta, 2015 Jun. PMID 25735211

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders.
      Title: Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia.
    2. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
      Title: Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to superoxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutaredoxin-2, mitochondrial
    Names
    glutaredoxin 2 (thioltransferase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394170.1 → NP_001381099.1  glutaredoxin-2, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6AXW1
      UniProtKB/TrEMBL
      A6ICN9
      Conserved Domains (1) summary
      cd03419
      Location:61 → 142
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    2. NM_001394171.1 → NP_001381100.1  glutaredoxin-2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICP1
      Conserved Domains (1) summary
      cd03419
      Location:28 → 109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    3. NM_001394172.1 → NP_001381101.1  glutaredoxin-2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICP1
      Conserved Domains (1) summary
      cd03419
      Location:28 → 109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    RNA

    1. NR_172084.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      58032199..58055061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271953.1 → XP_063128023.1  glutaredoxin-2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q6AXW1
      UniProtKB/TrEMBL
      A6ICN9

    2. XM_006249955.4 → XP_006250017.1  glutaredoxin-2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006250017.1

      UniProtKB/Swiss-Prot
      Q6AXW1
      UniProtKB/TrEMBL
      A6ICN9
      Related
      ENSRNOP00000056811.2, ENSRNOT00000060062.6
      Conserved Domains (1) summary
      cd03419
      Location:61 → 142
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    3. XM_039090231.2 → XP_038946159.1  glutaredoxin-2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6ICP1
      Conserved Domains (1) summary
      cd03419
      Location:28 → 109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    4. XM_008769526.4 → XP_008767748.1  glutaredoxin-2, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_008767748.1

      UniProtKB/TrEMBL
      A6ICP1
      Conserved Domains (1) summary
      cd03419
      Location:28 → 109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    5. XM_039090229.2 → XP_038946157.1  glutaredoxin-2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6ICP1
      Related
      ENSRNOP00000096477.1, ENSRNOT00000106322.2
      Conserved Domains (1) summary
      cd03419
      Location:28 → 109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    6. XM_063271954.1 → XP_063128024.1  glutaredoxin-2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6ICP1

    RNA

    1. XR_001840761.3 RNA Sequence

    2. XR_010056897.1 RNA Sequence

    3. XR_010056898.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXW1.2 GenPept UniProtKB/Swiss-Prot:Q6AXW1

    Gene LinkOut

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