Polrmt RNA polymerase mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Polrmtprovided by RGD
Official Full Name: RNA polymerase mitochondrialprovided by RGD
Primary source: RGD:1304599
See related: EnsemblRapid:ENSRNOG00000024879 AllianceGenome:RGD:1304599
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; DNA primase activity; and mitochondrial promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 70.0), Heart (RPKM 69.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10610149..10620411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9959532..9969791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12840907..12851153)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA primase activity	ISO Inferred from Sequence Orthology more info
enables DNA-directed 5'-3' RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase IV activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase V activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial single subunit type RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables plastid single subunit type RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in plastid transcription	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase IV	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase V	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of mitochondrial DNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase, mitochondrial

Names: polymerase (RNA) mitochondrial (DNA directed)

NP_001100236.1

EC 2.7.7.6

XP_006240921.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106766.1 → NP_001100236.1 DNA-directed RNA polymerase, mitochondrial

See identical proteins and their annotated locations for NP_001100236.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K8X9, D3ZYB6

Related

ENSRNOP00000032448.7, ENSRNOT00000039232.7

Conserved Domains (4) summary

TIGR02223
Location:22 → 164

ftsN; cell division protein FtsN

sd00004
Location:198 → 225

PPR; PPR repeat [structural motif]

pfam00940
Location:800 → 1202

RNA_pol; DNA-dependent RNA polymerase

pfam14700
Location:390 → 672

RPOL_N; DNA-directed RNA polymerase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10610149..10620411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240859.5 → XP_006240921.1 DNA-directed RNA polymerase, mitochondrial isoform X1

UniProtKB/TrEMBL

D3ZYB6

Conserved Domains (4) summary

TIGR02223
Location:22 → 164

ftsN; cell division protein FtsN

sd00004
Location:198 → 225

PPR; PPR repeat [structural motif]

pfam00940
Location:801 → 1203

RNA_pol; DNA-dependent RNA polymerase

pfam14700
Location:391 → 673

RPOL_N; DNA-directed RNA polymerase N-terminal