Cd86 CD86 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd86provided by RGD
Official Full Name: CD86 moleculeprovided by RGD
Primary source: RGD:628714
See related: EnsemblRapid:ENSRNOG00000038835 AllianceGenome:RGD:628714
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B7-2
Summary: Enables signaling receptor binding activity. Involved in several processes, including defense response to symbiont; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 119.3), Thymus (RPKM 50.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (77647565..77706178)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (64142193..64200816)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (67060305..67117990)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
Title: Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.
B7.1 and B7.2 are expressed in the eye at different times during experimental autoimmune anterior uveitis. Both B7 molecules are required for the induction of EAAU, although they probably have different roles.
Title: Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU).
Lumbar spinal expression of the co-stimulatory molecules CD86 and CD80 in a rat model of neuropathy results in intense CD86 microglial expression in lumbar spinal cord after injury but no expression of CD80.
Title: Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Chondrogenic differentiation may increase the immunogenicity of mesenchymal stem cells, leading to stimulation of dendritic cells and upregulation of B7 molecules may be partially responsible for this event.
Title: Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell proliferation involved in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to virus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid dendritic cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to yeast	IEP Inferred from Expression Pattern more info	PubMed
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-lymphocyte activation antigen CD86

Names: cd86 antigen; membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020081.3 → NP_064466.1 T-lymphocyte activation antigen CD86 precursor

See identical proteins and their annotated locations for NP_064466.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A0G2JXF7, A0A8J8XMF6, A0A9K3Y6P6, F1LNG0, O35531

Related

ENSRNOP00000070253.2, ENSRNOT00000078936.3

Conserved Domains (2) summary

smart00406
Location:40 → 117

IGv; Immunoglobulin V-Type

cl11960
Location:143 → 224

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

77647565..77706178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248399.5 → XP_006248461.1 T-lymphocyte activation antigen CD86 isoform X1

See identical proteins and their annotated locations for XP_006248461.1

UniProtKB/TrEMBL

A0A8J8XMF6, A6IRC5

Related

ENSRNOP00000101190.1, ENSRNOT00000159927.1

Conserved Domains (3) summary

cd00096
Location:133 → 139

Ig; Ig strand A [structural motif]

cd16087
Location:20 → 127

IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86

cl11960
Location:130 → 213

Ig; Immunoglobulin domain
XM_039088600.2 → XP_038944528.1 T-lymphocyte activation antigen CD86 isoform X1

UniProtKB/TrEMBL

A0A8J8XMF6, A6IRC5

Conserved Domains (3) summary

cd00096
Location:133 → 139

Ig; Ig strand A [structural motif]

cd16087
Location:20 → 127

IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86

cl11960
Location:130 → 213

Ig; Immunoglobulin domain