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    Poc1a POC1 centriolar protein A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501048, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Poc1aprovided by RGD
    Official Full Name
    POC1 centriolar protein Aprovided by RGD
    Primary source
    RGD:1565004
    See related
    EnsemblRapid:ENSRNOG00000037295 AllianceGenome:RGD:1565004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr51a; RGD1565004
    Summary
    Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including growth plate cartilage chondrocyte development; non-motile cilium assembly; and positive regulation of centrosome duplication. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in centriole and ciliary basal body. Orthologous to human POC1A (POC1 centriolar protein A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 23.6), Testes (RPKM 17.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Poc1a in Genome Data Viewer
    Location:
    8q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115801335..115869812)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106922058..106991678)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114982764..115050844)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene toll-like receptor 9 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene dual specificity phosphatase 7 Neighboring gene aminoacylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. Geister KA, et al. PLoS Genet, 2015 Oct. PMID 26496357, Free PMC Article
    2. Poc1A and Poc1B act together in human cells to ensure centriole integrity. Venoux M, et al. J Cell Sci, 2013 Jan 1. PMID 23015594, Free PMC Article
    3. Basal body stability and ciliogenesis requires the conserved component Poc1. Pearson CG, et al. J Cell Biol, 2009 Dec 14. PMID 20008567, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within growth plate cartilage chondrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    POC1 centriolar protein homolog A
    Names
    WD repeat domain 51A
    WD repeat-containing protein 51A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109296.2 → NP_001102766.2  POC1 centriolar protein homolog A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ABU4
      Related
      ENSRNOP00000080624.2, ENSRNOT00000096090.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115801335..115869812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081983.2 → XP_038937911.1  POC1 centriolar protein homolog A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQ11
      Related
      ENSRNOP00000079424.2, ENSRNOT00000095943.2
      Conserved Domains (2) summary
      cd00200
      Location:11 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:23 → 59
      7WD40; WD40 repeat [structural motif]

    2. XM_039081982.2 → XP_038937910.1  POC1 centriolar protein homolog A isoform X1

      Related
      ENSRNOP00000038175.8, ENSRNOT00000038166.8
      Conserved Domains (2) summary
      cd00200
      Location:11 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:23 → 59
      7WD40; WD40 repeat [structural motif]

    3. XM_039081985.2 → XP_038937913.1  POC1 centriolar protein homolog A isoform X2

      UniProtKB/TrEMBL
      A6I2Q6
      Conserved Domains (2) summary
      cd00200
      Location:2 → 261
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:26 → 63
      7WD40; WD40 repeat [structural motif]

    4. XM_039081987.2 → XP_038937915.1  POC1 centriolar protein homolog A isoform X2

      UniProtKB/TrEMBL
      A6I2Q6
      Conserved Domains (2) summary
      cd00200
      Location:2 → 261
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:26 → 63
      7WD40; WD40 repeat [structural motif]

    5. XM_039081984.2 → XP_038937912.1  POC1 centriolar protein homolog A isoform X4

      Conserved Domains (2) summary
      cd00200
      Location:4 → 212
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 56
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_010054017.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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