Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aipl1provided by RGD
Official Full Name: aryl hydrocarbon receptor-interacting protein-like 1provided by RGD
Primary source: RGD:70906
See related: EnsemblRapid:ENSRNOG00000007889 AllianceGenome:RGD:70906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable farnesylated protein binding activity. Predicted to act upstream of or within several processes, including phototransduction, visible light; protein farnesylation; and regulation of opsin-mediated signaling pathway. Predicted to be located in cytosol; nuclear speck; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; and retinitis pigmentosa. Orthologous to human AIPL1 (aryl hydrocarbon receptor interacting protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 1.2), Brain (RPKM 0.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (57154226..57163455, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (56655693..56664922, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (58599690..58631194, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU028104 (e-PCR)
- UniSTS:112655

AI848332 (e-PCR)
- UniSTS:180244

RH133622 (e-PCR)
- UniSTS:216905

RH133740 (e-PCR)
- UniSTS:217023

RH128893 (e-PCR)
- UniSTS:212201

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables farnesylated protein binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phototransduction, visible light	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein farnesylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of opsin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aryl-hydrocarbon-interacting protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021590.2 → NP_067601.1 aryl-hydrocarbon-interacting protein-like 1

See identical proteins and their annotated locations for NP_067601.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9JLG9

UniProtKB/TrEMBL

A6HGD1

Related

ENSRNOP00000010533.1, ENSRNOT00000010533.4

Conserved Domains (3) summary

sd00006
Location:180 → 224

TPR; TPR repeat [structural motif]

pfam13414
Location:180 → 261

TPR_11; TPR repeat

cl19519
Location:30 → 89

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase