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    Cela1 chymotrypsin like elastase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24331, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cela1provided by RGD
    Official Full Name
    chymotrypsin like elastase 1provided by RGD
    Primary source
    RGD:2547
    See related
    EnsemblRapid:ENSRNOG00000080453 AllianceGenome:RGD:2547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ela1; ELAI1; RATELAI1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; phagocytic cup; and podosome. Predicted to be active in extracellular space. Orthologous to human CELA1 (chymotrypsin like elastase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 4069.6) and Liver (RPKM 1220.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cela1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133651939..133665136, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131773161..131786300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142305337..142318621, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene solute carrier family 4 member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Elastase involvement in extracellular and intracellular collagen degradation during postpartum involution of the uterus. Ryvnyak VV, et al. Bull Exp Biol Med, 2003 Aug. PMID 14631512
    2. Isolation and characterization of rat pancreatic elastase. Largman C. Biochemistry, 1983 Aug 2. PMID 6555050
    3. Electron-histochemical location of cathepsin D and elastase in the uterus. Ryvnyak VV, et al. Bull Exp Biol Med, 2003 Aug. PMID 14631510
    4. Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences. MacDonald RJ, et al. Biochemistry, 1982 Mar 16. PMID 6918221
    5. Structure of the two related elastase genes expressed in the rat pancreas. Swift GH, et al. J Biol Chem, 1984 Nov 25. PMID 6094548

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the location of elastase in rat uterus during its postpartum involution.
      Title: Elastase involvement in extracellular and intracellular collagen degradation during postpartum involution of the uterus.
    2. Data show that both cathepsin D and elastase are present in lysosomes of smooth-muscle cells, macrophages, and fibroblasts of the myometrium.
      Title: Electron-histochemical location of cathepsin D and elastase in the uterus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within digestive system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within elastin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within exocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pancreas morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane tubulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in podosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chymotrypsin-like elastase family member 1
    Names
    chymotrypsin-like elastase family, member 1
    elastase 1, pancreatic
    elastase-1
    NP_036684.1
    XP_063119047.1
    XP_063119048.1
    XP_063119049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012552.4 → NP_036684.1  chymotrypsin-like elastase family member 1 precursor

      See identical proteins and their annotated locations for NP_036684.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P00773
      UniProtKB/TrEMBL
      A0A0G2JSI5, A6KCL6
      Related
      ENSRNOP00000006351.4, ENSRNOT00000006351.8
      Conserved Domains (2) summary
      smart00020
      Location:26 → 258
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:27 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133651939..133665136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262978.1 → XP_063119048.1  chymotrypsin-like elastase family member 1 isoform X2

    2. XM_063262977.1 → XP_063119047.1  chymotrypsin-like elastase family member 1 isoform X1

    3. XM_063262979.1 → XP_063119049.1  chymotrypsin-like elastase family member 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00773.1 GenPept UniProtKB/Swiss-Prot:P00773

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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