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    Slc25a44 solute carrier family 25, member 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a44provided by RGD
    Official Full Name
    solute carrier family 25, member 44provided by RGD
    Primary source
    RGD:1307244
    See related
    EnsemblRapid:ENSRNOG00000025269 AllianceGenome:RGD:1307244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307244
    Summary
    Predicted to enable branched-chain amino acid transmembrane transporter activity. Predicted to be involved in branched-chain amino acid catabolic process; branched-chain amino acid transport; and regulation of cold-induced thermogenesis. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A44 (solute carrier family 25 member 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 108.4), Brain (RPKM 107.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a44 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176166136..176180965, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173868317..173883137, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187772013..187786829, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene polyamine-modulated factor 1 Neighboring gene uncharacterized LOC134485637 Neighboring gene uncharacterized LOC134485636 Neighboring gene semaphorin 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Yoneshiro T, et al. Nature, 2019 Aug. PMID 31435015, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables branched-chain amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in branched-chain amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in branched-chain amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in branched-chain amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108947.1 → NP_001102417.1  solute carrier family 25 member 44

      See identical proteins and their annotated locations for NP_001102417.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A0A0U1RRT2, A6J674, A6J675
      Related
      ENSRNOP00000075803.2, ENSRNOT00000092612.3
      Conserved Domains (2) summary
      PTZ00169
      Location:43 → 325
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:128 → 237
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176166136..176180965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102760.2 → XP_038958688.1  solute carrier family 25 member 44 isoform X3

      UniProtKB/TrEMBL
      D3ZSN7
      Conserved Domains (1) summary
      pfam00153
      Location:128 → 227
      Mito_carr; Mitochondrial carrier protein

    2. XM_039102761.2 → XP_038958689.1  solute carrier family 25 member 44 isoform X4

      UniProtKB/TrEMBL
      D3ZSN7
      Related
      ENSRNOP00000059753.3, ENSRNOT00000068360.4
      Conserved Domains (1) summary
      pfam00153
      Location:128 → 227
      Mito_carr; Mitochondrial carrier protein

    3. XM_039102759.2 → XP_038958687.1  solute carrier family 25 member 44 isoform X1

      UniProtKB/TrEMBL
      A6J674
      Related
      ENSRNOP00000075772.3, ENSRNOT00000092257.3
      Conserved Domains (1) summary
      pfam00153
      Location:120 → 229
      Mito_carr; Mitochondrial carrier protein

    4. XM_006232720.4 → XP_006232782.1  solute carrier family 25 member 44 isoform X2

      See identical proteins and their annotated locations for XP_006232782.1

      UniProtKB/TrEMBL
      A6J674
      Conserved Domains (1) summary
      pfam00153
      Location:105 → 214
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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