Ostm1 osteoclastogenesis associated transmembrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ostm1provided by RGD
Official Full Name: osteoclastogenesis associated transmembrane protein 1provided by RGD
Primary source: RGD:1564976
See related: EnsemblRapid:ENSRNOG00000037647 AllianceGenome:RGD:1564976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gipn
Summary: Predicted to be involved in osteoclast differentiation and transepithelial chloride transport. Predicted to be located in lysosomal membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 118.1), Kidney (RPKM 95.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (47653696..47769248)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (46071657..46187049)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (47394979..47430304)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIPN (Ostm1) is a 38-kDa protein with an N-terminal Leu-rich region, a central RING finger-like domain & a C-terminal transmembrane domain. It has E3 ubiquitin ligase activity. It is involved in the degradation of G alpha i3 subunits via proteasomes.
Title: Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: osteopetrosis-associated transmembrane protein 1

Names: GAIP interacting protein N terminus; osteopetrosis associated transmembrane protein 1; osteopetrosis associated transmembrane protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029925.2 → NP_001025096.1 osteopetrosis-associated transmembrane protein 1 precursor

See identical proteins and their annotated locations for NP_001025096.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

F1LP89, Q4QQU9

Related

ENSRNOP00000091994.1, ENSRNOT00000114998.3

Conserved Domains (1) summary

pfam09777
Location:88 → 332

OSTMP1; Osteopetrosis-associated transmembrane protein 1 precursor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

47653696..47769248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099031.2 → XP_038954959.1 osteopetrosis-associated transmembrane protein 1 isoform X2

Conserved Domains (1) summary

pfam09777
Location:1 → 181

OSTMP1; Osteopetrosis-associated transmembrane protein 1 precursor
XM_006256577.5 → XP_006256639.1 osteopetrosis-associated transmembrane protein 1 isoform X1

UniProtKB/TrEMBL

A0A8J8Y8J8

Conserved Domains (1) summary

pfam09777
Location:88 → 345

OSTMP1; Osteopetrosis-associated transmembrane protein 1 precursor