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    Cops4 COP9 signalosome subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360915, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cops4provided by RGD
    Official Full Name
    COP9 signalosome subunit 4provided by RGD
    Primary source
    RGD:1302952
    See related
    EnsemblRapid:ENSRNOG00000023650 AllianceGenome:RGD:1302952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein deneddylation. Located in synaptic vesicle. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 374.8), Testes (RPKM 355.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cops4 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9382897..9413216, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9078579..9108788, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10718863..10749134, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481703 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2-like Neighboring gene placenta associated 8 Neighboring gene uncharacterized LOC102550950 Neighboring gene lin-54 DREAM MuvB core complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. Granata A, et al. EMBO J, 2011 Jan 5. PMID 21102408, Free PMC Article
    2. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
    3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
    4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
    5. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94896

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 4
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 4
    JAB1-containing signalosome subunit 4
    SGN4
    signalosome subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004275.1 → NP_001004275.1  COP9 signalosome complex subunit 4

      See identical proteins and their annotated locations for NP_001004275.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079384
      UniProtKB/Swiss-Prot
      Q68FS2
      UniProtKB/TrEMBL
      A0A8L2Q0P3, A6K5Z4
      Related
      ENSRNOP00000003046.5, ENSRNOT00000003046.8
      Conserved Domains (3) summary
      COG5071
      Location:71 → 377
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:365 → 406
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:264 → 362
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9382897..9413216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273329.1 → XP_063129399.1  COP9 signalosome complex subunit 4 isoform X2

    2. XM_063273328.1 → XP_063129398.1  COP9 signalosome complex subunit 4 isoform X1

    3. XM_063273330.1 → XP_063129400.1  COP9 signalosome complex subunit 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FS2.1 GenPept UniProtKB/Swiss-Prot:Q68FS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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