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    Myt1l myelin transcription factor 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116668, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Myt1lprovided by RGD
    Official Full Name
    myelin transcription factor 1-likeprovided by RGD
    Primary source
    RGD:620550
    See related
    EnsemblRapid:ENSRNOG00000004269 AllianceGenome:RGD:620550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nzf1; Nzf-1; Nztf1
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; retinoic acid-responsive element binding activity; and transition metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 192.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myt1l in Genome Data Viewer
    Location:
    6q16
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (51892858..52291830)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (46164742..46564234)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (48452385..48843443)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554981 Neighboring gene uncharacterized LOC134479356 Neighboring gene uncharacterized LOC134479355 Neighboring gene uncharacterized LOC134479354 Neighboring gene peroxidasin Neighboring gene thyroid peroxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding. Berkovits-Cymet HJ, et al. Biochemistry, 2004 Feb 3. PMID 14744132
    2. Metal and DNA binding properties of a two-domain fragment of neural zinc finger factor 1, a CCHC-type zinc binding protein. Berkovits HJ, et al. Biochemistry, 1999 Dec 21. PMID 10606515
    3. X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Bellefroid EJ, et al. Cell, 1996 Dec 27. PMID 8980226
    4. Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Mall M, et al. Nature, 2017 Apr 13. PMID 28379941, Free PMC Article
    5. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Wapinski OL, et al. Cell, 2013 Oct 24. PMID 24243019, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cobalt ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion sequestering activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables metal ion sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinoic acid-responsive element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinoic acid-responsive element binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myelin transcription factor 1-like protein
    Names
    myT1-L
    neural zinc finger factor 1
    neural zinc finger transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053888.2 → NP_446340.2  myelin transcription factor 1-like protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      D4A9W2, P70475, P70589
      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1032 → 1186
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:903 → 931
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:620 → 871
      MYT1; Myelin transcription factor 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      51892858..52291830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111668.2 → XP_038967596.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    2. XM_063261464.1 → XP_063117534.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      D4A9W2, P70475, P70589

    3. XM_063261488.1 → XP_063117558.1  myelin transcription factor 1-like protein isoform X18

      Related
      ENSRNOP00000005905.7, ENSRNOT00000005905.8

    4. XM_039111682.2 → XP_038967610.1  myelin transcription factor 1-like protein isoform X5

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1013 → 1167
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:884 → 912
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:601 → 852
      MYT1; Myelin transcription factor 1

    5. XM_063261460.1 → XP_063117530.1  myelin transcription factor 1-like protein isoform X1

    6. XM_063261482.1 → XP_063117552.1  myelin transcription factor 1-like protein isoform X9

    7. XM_039111676.2 → XP_038967604.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    8. XM_039111677.2 → XP_038967605.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    9. XM_039111669.2 → XP_038967597.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    10. XM_063261463.1 → XP_063117533.1  myelin transcription factor 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A5H1ZRT6

    11. XM_063261469.1 → XP_063117539.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A6HB26

    12. XM_063261473.1 → XP_063117543.1  myelin transcription factor 1-like protein isoform X5

    13. XM_039111684.2 → XP_038967612.1  myelin transcription factor 1-like protein isoform X11

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      TIGR04523
      Location:1061 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    14. XM_039111683.2 → XP_038967611.1  myelin transcription factor 1-like protein isoform X6

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1013 → 1167
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:933 → 961
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    15. XM_039111689.2 → XP_038967617.1  myelin transcription factor 1-like protein isoform X15

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:989 → 1143
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:860 → 888
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:577 → 828
      MYT1; Myelin transcription factor 1

    16. XM_039111686.2 → XP_038967614.1  myelin transcription factor 1-like protein isoform X12

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      TIGR04523
      Location:1059 → 1139
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:903 → 931
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:620 → 871
      MYT1; Myelin transcription factor 1

    17. XM_039111690.2 → XP_038967618.1  myelin transcription factor 1-like protein isoform X17

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:987 → 1141
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:858 → 886
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:575 → 826
      MYT1; Myelin transcription factor 1

    18. XM_039111667.2 → XP_038967595.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    19. XM_063261459.1 → XP_063117529.1  myelin transcription factor 1-like protein isoform X1

    20. XM_063261476.1 → XP_063117546.1  myelin transcription factor 1-like protein isoform X5

    21. XM_039111672.2 → XP_038967600.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    22. XM_039111681.2 → XP_038967609.1  myelin transcription factor 1-like protein isoform X5

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1013 → 1167
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:884 → 912
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:601 → 852
      MYT1; Myelin transcription factor 1

    23. XM_039111673.2 → XP_038967601.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    24. XM_063261477.1 → XP_063117547.1  myelin transcription factor 1-like protein isoform X5

    25. XM_039111670.2 → XP_038967598.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    26. XM_063261474.1 → XP_063117544.1  myelin transcription factor 1-like protein isoform X5

    27. XM_039111678.2 → XP_038967606.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    28. XM_063261478.1 → XP_063117548.1  myelin transcription factor 1-like protein isoform X5

    29. XM_063261479.1 → XP_063117549.1  myelin transcription factor 1-like protein isoform X7

    30. XM_063261486.1 → XP_063117556.1  myelin transcription factor 1-like protein isoform X14

    31. XM_063261466.1 → XP_063117536.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      D4A9W2, P70475, P70589

    32. XM_063261481.1 → XP_063117551.1  myelin transcription factor 1-like protein isoform X9

    33. XM_063261467.1 → XP_063117537.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      D4A9W2, P70475, P70589

    34. XM_063261484.1 → XP_063117554.1  myelin transcription factor 1-like protein isoform X9

    35. XM_063261465.1 → XP_063117535.1  myelin transcription factor 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      D4A9W2, P70475, P70589
      Related
      ENSRNOP00000109546.1, ENSRNOT00000148709.1

    36. XM_063261483.1 → XP_063117553.1  myelin transcription factor 1-like protein isoform X9

    37. XM_063261487.1 → XP_063117557.1  myelin transcription factor 1-like protein isoform X16

    38. XM_063261462.1 → XP_063117532.1  myelin transcription factor 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A5H1ZRT6

    39. XM_039111687.2 → XP_038967615.1  myelin transcription factor 1-like protein isoform X13

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1058 → 1125
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:903 → 931
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:620 → 871
      MYT1; Myelin transcription factor 1

    40. XM_063261480.1 → XP_063117550.1  myelin transcription factor 1-like protein isoform X8

    41. XM_063261468.1 → XP_063117538.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A6HB26

    42. XM_039111680.2 → XP_038967608.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A6HB26, F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1032 → 1184
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:903 → 931
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:620 → 871
      MYT1; Myelin transcription factor 1

    43. XM_063261470.1 → XP_063117540.1  myelin transcription factor 1-like protein isoform X4

      UniProtKB/TrEMBL
      A6HB26

    44. XM_063261471.1 → XP_063117541.1  myelin transcription factor 1-like protein isoform X5

    45. XM_063261485.1 → XP_063117555.1  myelin transcription factor 1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A056
      Related
      ENSRNOP00000084839.1, ENSRNOT00000095119.2

    46. XM_039111675.2 → XP_038967603.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    47. XM_063261475.1 → XP_063117545.1  myelin transcription factor 1-like protein isoform X5

    48. XM_039111671.2 → XP_038967599.1  myelin transcription factor 1-like protein isoform X1

      UniProtKB/TrEMBL
      F1M8L4
      Conserved Domains (3) summary
      COG1196
      Location:1034 → 1188
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01530
      Location:905 → 933
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:622 → 873
      MYT1; Myelin transcription factor 1

    49. XM_063261461.1 → XP_063117531.1  myelin transcription factor 1-like protein isoform X1

      Related
      ENSRNOP00000045413.6, ENSRNOT00000044310.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70475.3 GenPept UniProtKB/Swiss-Prot:P70475

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