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    Golga4 golgin A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golga4provided by RGD
    Official Full Name
    golgin A4provided by RGD
    Primary source
    RGD:1591925
    See related
    EnsemblRapid:ENSRNOG00000085953 AllianceGenome:RGD:1591925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and positive regulation of axon extension. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 298.5), Heart (RPKM 230.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Golga4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127085830..127163227)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118208200..118285003)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127171221..127248938)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548091 Neighboring gene eomesodermin Neighboring gene integrin subunit alpha 9 Neighboring gene transfer RNA alanine (anticodon GGC) 2 Neighboring gene uncharacterized LOC134480111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development. Cowan DA, et al. DNA Cell Biol, 2002 Jul. PMID 12162805
    2. Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. Kakinuma T, et al. Exp Cell Res, 2004 Aug 15. PMID 15265687
    3. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. Panic B, et al. Mol Cell, 2003 Oct. PMID 14580338
    4. A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Burgo A, et al. Dev Cell, 2012 Jul 17. PMID 22705394
    5. Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. Nishimoto-Morita K, et al. J Biol Chem, 2009 Apr 17. PMID 19224922, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 4
    Names
    golgi autoantigen, golgin subfamily a, 4
    tGolgin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429208.1 → NP_001416137.1  golgin subfamily A member 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5U4E6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127085830..127163227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266012.1 → XP_063122082.1  golgin subfamily A member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U4E6

    2. XM_063266013.1 → XP_063122083.1  golgin subfamily A member 4 isoform X2

      Related
      ENSRNOP00000098962.1, ENSRNOT00000154270.1

    3. XM_063266021.1 → XP_063122091.1  golgin subfamily A member 4 isoform X9

      UniProtKB/Swiss-Prot
      Q5U4E6

    4. XM_063266014.1 → XP_063122084.1  golgin subfamily A member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q5U4E6

    5. XM_063266017.1 → XP_063122087.1  golgin subfamily A member 4 isoform X6

      UniProtKB/Swiss-Prot
      Q5U4E6

    6. XM_063266022.1 → XP_063122092.1  golgin subfamily A member 4 isoform X10

      UniProtKB/Swiss-Prot
      Q5U4E6

    7. XM_063266028.1 → XP_063122098.1  golgin subfamily A member 4 isoform X16

      UniProtKB/Swiss-Prot
      Q5U4E6

    8. XM_063266019.1 → XP_063122089.1  golgin subfamily A member 4 isoform X7

      UniProtKB/Swiss-Prot
      Q5U4E6

    9. XM_063266020.1 → XP_063122090.1  golgin subfamily A member 4 isoform X8

      UniProtKB/Swiss-Prot
      Q5U4E6
      Related
      ENSRNOP00000112165.1, ENSRNOT00000158028.1

    10. XM_063266023.1 → XP_063122093.1  golgin subfamily A member 4 isoform X11

      UniProtKB/Swiss-Prot
      Q5U4E6

    11. XM_063266025.1 → XP_063122095.1  golgin subfamily A member 4 isoform X13

      UniProtKB/Swiss-Prot
      Q5U4E6
      Related
      ENSRNOP00000103026.1, ENSRNOT00000136370.1

    12. XM_063266026.1 → XP_063122096.1  golgin subfamily A member 4 isoform X14

      UniProtKB/Swiss-Prot
      Q5U4E6

    13. XM_063266029.1 → XP_063122099.1  golgin subfamily A member 4 isoform X17

      UniProtKB/TrEMBL
      A6I3U3

    14. XM_063266016.1 → XP_063122086.1  golgin subfamily A member 4 isoform X5

      UniProtKB/Swiss-Prot
      Q5U4E6

    15. XM_063266015.1 → XP_063122085.1  golgin subfamily A member 4 isoform X4

      UniProtKB/Swiss-Prot
      Q5U4E6

    16. XM_063266024.1 → XP_063122094.1  golgin subfamily A member 4 isoform X12

      UniProtKB/Swiss-Prot
      Q5U4E6

    17. XM_063266027.1 → XP_063122097.1  golgin subfamily A member 4 isoform X15

      UniProtKB/Swiss-Prot
      Q5U4E6
      Related
      ENSRNOP00000099161.1, ENSRNOT00000170912.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191080.1: Suppressed sequence

      Description
      NM_001191080.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4E6.2 GenPept UniProtKB/Swiss-Prot:Q5U4E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.