Lgals6 lectin, galactose binding, soluble 6 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Lgals6provided by MGI
Official Full Name: lectin, galactose binding, soluble 6provided by MGI
Primary source: MGI:MGI:107535
See related: AllianceGenome:MGI:107535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: galectin-6
Summary: Predicted to enable carbohydrate binding activity. Acts upstream of or within antibacterial peptide biosynthetic process. Is expressed in gut; heart; liver; metanephros; and spleen. Orthologous to human LGALS4 (galectin 4). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

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Location:: 7 B1; 7

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that prion protein PrPC combined with galectin-3 and -6 can act as a receptor for murine leukemia virus (MuLV).
Title: Cellular Prion Protein Combined with Galectin-3 and -6 Affects the Infectivity Titer of an Endogenous Retrovirus Assayed in Hippocampal Neuronal Cells.
Galectin-6 is a skin anti-microbial peptide that is modulated by the skin barrier and microbiome
Title: Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.
patterns of galectin-4 and galectin-6 expression in the normal and the dextran sodium sulfate (DSS)-damaged digestive
Title: Expression patterns suggest that despite considerable functional redundancy, galectin-4 and -6 play distinct roles in normal and damaged mouse digestive tract.
The example of a 2-million-year-old segmental duplication at the origin of the Lgals4 and Lgals6 genes in the mouse genome, is analysed.
Title: Lgals6, a 2-million-year-old gene in mice: a case of positive Darwinian selection and presence/absence polymorphism.
Results indicated that galectin-6 is expressed in the small intestine, colon, liver, kidney, spleen and heart and P19X1 cells of mouse but not in BW-5147 and 3T3 cell lines.
Title: Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.

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General gene information

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Markers

RH139632 (e-PCR)
- UniSTS:221716

RH140494 (e-PCR)
- UniSTS:221716

Lgals6 (e-PCR), detects polymorphism
- UniSTS:525640

Lgals6 (e-PCR), detects polymorphism
- UniSTS:525641

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galectin-6

Names: gal-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.