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    Marchf7 membrane associated ring-CH-type finger 7 [ Mus musculus (house mouse) ]

    Gene ID: 57438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marchf7provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 7provided by MGI
    Primary source
    MGI:MGI:1931053
    See related
    Ensembl:ENSMUSG00000026977 AllianceGenome:MGI:1931053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Axo; Axot; March7; Gtrgeo17
    Summary
    Enables enzyme binding activity and ubiquitin binding activity. Involved in protein autoubiquitination. Acts upstream of or within negative regulation of T cell proliferation and regulation of tolerance induction. Located in cytosol; nucleus; and plasma membrane. Is expressed in brain; early conceptus; and telencephalon. Orthologous to human MARCHF7 (membrane associated ring-CH-type finger 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.5), CNS E18 (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Marchf7 in Genome Data Viewer
    Location:
    2 C1.1; 2 34.46 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60040086..60079555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60209936..60248385)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-positive B cell enhancer ABC_E5921 Neighboring gene STARR-positive B cell enhancer ABC_E4454 Neighboring gene predicted gene 13570 Neighboring gene STARR-seq mESC enhancer starr_04605 Neighboring gene lactate dehydrogenase A, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5922 Neighboring gene STARR-seq mESC enhancer starr_04606 Neighboring gene STARR-seq mESC enhancer starr_04607 Neighboring gene STARR-seq mESC enhancer starr_04608 Neighboring gene ribosomal protein L10A, pseudogene 4 Neighboring gene CD302 antigen Neighboring gene lymphocyte antigen 75 Neighboring gene predicted gene 13571

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. Metcalfe SM, et al. FEBS Lett, 2005 Jan 31. PMID 15670816
    2. A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor. Thompson LH, et al. Cell Cycle, 2010 Oct 15. PMID 20962578, Free PMC Article
    3. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. Muthukumarana PA, et al. Int Immunopharmacol, 2006 Dec 20. PMID 17161353
    4. GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis. Chen T, et al. Cell Death Differ, 2023 Jul. PMID 37337032, Free PMC Article
    5. A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity. Mollah MB, et al. BMC Genet, 2010 Sep 23. PMID 20860848, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that T cells retain responsiveness to a LIF/Nanog axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
      Title: A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
    2. Data suggest that thymic Foxp3+T cell development is influenced by axotrophin.
      Title: Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF7
    Names
    E3 ubiquitin-protein ligase MARCH7
    MARCH-VII
    RING-type E3 ubiquitin transferase MARCH7
    RING-type E3 ubiquitin transferase MARCHF7
    axotrophin
    gene trap ROSA b-geo 17
    membrane-associated RING finger protein 7
    membrane-associated RING-CH protein VII
    membrane-associated ring finger (C3HC4) 7
    NP_001405416.1
    NP_001405417.1
    NP_001405418.1
    NP_001405419.1
    NP_001405420.1
    NP_001405421.1
    NP_001405422.1
    NP_065600.1
    XP_036018314.1
    XP_036018315.1
    XP_036018320.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418487.1 → NP_001405416.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935326

    2. NM_001418488.1 → NP_001405417.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935326

    3. NM_001418489.1 → NP_001405418.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL935326
      UniProtKB/Swiss-Prot
      Q9WV66
      Related
      ENSMUSP00000099808.2, ENSMUST00000102747.8

    4. NM_001418490.1 → NP_001405419.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL935326

    5. NM_001418491.1 → NP_001405420.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL935326

    6. NM_001418492.1 → NP_001405421.1  E3 ubiquitin-protein ligase MARCHF7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL935326

    7. NM_001418493.1 → NP_001405422.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL935326

    8. NM_020575.3 → NP_065600.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

      See identical proteins and their annotated locations for NP_065600.1

      Status: VALIDATED

      Source sequence(s)
      AL935326
      Consensus CDS
      CCDS16057.1
      UniProtKB/Swiss-Prot
      Q9WV66
      Related
      ENSMUSP00000099809.5, ENSMUST00000102748.11
      Conserved Domains (2) summary
      cd00162
      Location:554 → 609
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:554 → 612
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_184755.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935326

    2. NR_184756.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935326

    3. NR_184757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935326

    4. NR_184758.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935326

    5. NR_184759.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935326

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      60040086..60079555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162421.1 → XP_036018314.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      Conserved Domains (2) summary
      cd00162
      Location:554 → 609
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:554 → 612
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_036162427.1 → XP_036018320.1  E3 ubiquitin-protein ligase MARCHF7 isoform X5

      Conserved Domains (2) summary
      cd00162
      Location:263 → 318
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:263 → 321
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_036162422.1 → XP_036018315.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      Conserved Domains (2) summary
      cd00162
      Location:554 → 609
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:554 → 612
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_004940676.1 RNA Sequence

    2. XR_004940674.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV66.1 GenPept UniProtKB/Swiss-Prot:Q9WV66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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