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    SPDYE2 speedy/RINGO cell cycle regulator family member E2 [ Homo sapiens (human) ]

    Gene ID: 441273, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPDYE2provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E2provided by HGNC
    Primary source
    HGNC:HGNC:33841
    See related
    Ensembl:ENSG00000205238 MIM:617624; AllianceGenome:HGNC:33841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPDYB2L1; SPDYB2-L1
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 4.7), spleen (RPKM 2.6) and 24 other tissues See more
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    Genomic context

    See SPDYE2 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102551226..102565227)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103865641..103881058)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102191673..102203985)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 4B Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102212169-102212830 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:102213197-102213370 Neighboring gene uncharacterized LOC124901712 Neighboring gene RNA polymerase II subunit J3 Neighboring gene RAS p21 protein activator 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    speedy protein E2
    Names
    Speedy B2-like 1
    putative Speedy protein E2
    speedy homolog E2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031618.3NP_001026789.2  speedy protein E2

      See identical proteins and their annotated locations for NP_001026789.2

      Status: VALIDATED

      Source sequence(s)
      AC093668, AK302217, BF809327, DR731150
      Consensus CDS
      CCDS34716.2
      UniProtKB/Swiss-Prot
      B4DY11, Q495Y8
      UniProtKB/TrEMBL
      I6XC90
      Related
      ENSP00000421686.1, ENST00000507918.6
      Conserved Domains (1) summary
      pfam11357
      Location:194398
      Spy1; Cell cycle regulatory protein
    2. NM_001396242.1NP_001383171.1  speedy protein E2

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS34716.2
      UniProtKB/Swiss-Prot
      B4DY11, Q495Y8
      UniProtKB/TrEMBL
      I6XC90
      Related
      ENSP00000509749.1, ENST00000691607.2
      Conserved Domains (1) summary
      pfam11357
      Location:194398
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102551226..102565227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516237.4XP_011514539.1  speedy protein E2 isoform X1

      Conserved Domains (1) summary
      pfam11357
      Location:194303
      Spy1; Cell cycle regulatory protein
    2. XM_047420405.1XP_047276361.1  speedy protein E2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103865641..103881058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358263.1XP_054214238.1  speedy protein E2 isoform X5

      UniProtKB/TrEMBL
      A0A0J9YVZ0
    2. XM_054358262.1XP_054214237.1  speedy protein E2 isoform X4

    3. XM_054358261.1XP_054214236.1  speedy protein E2 isoform X3