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    EIF4G3 eukaryotic translation initiation factor 4 gamma 3 [ Homo sapiens (human) ]

    Gene ID: 8672, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EIF4G3provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma 3provided by HGNC
    Primary source
    HGNC:HGNC:3298
    See related
    Ensembl:ENSG00000075151 MIM:603929; AllianceGenome:HGNC:3298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eIF4G 3; eIF4GII; eIF-4G 3
    Summary
    The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
    Expression
    Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF4G3 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20806292..21176897, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20632859..21003583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21132785..21503390, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054065-21054727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054728-21055389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21056983-21057676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21057677-21058368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21058590-21059262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21059263-21059933 Neighboring gene SH2 domain containing 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21112523-21112715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 376 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146362-21146862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146863-21147363 Neighboring gene RNA, U7 small nuclear 200 pseudogene Neighboring gene uncharacterized LOC105376830 Neighboring gene uncharacterized LOC105376829 Neighboring gene NFE2L2 motif-containing MPRA enhancer 38 Neighboring gene Sharpr-MPRA regulatory region 2723 Neighboring gene microRNA 1256 Neighboring gene ribosomal protein S15a pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21394491-21394661 Neighboring gene MPRA-validated peak106 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 325 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 27 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21544531-21544736 Neighboring gene MPRA-validated peak108 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21562319-21562819 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:21587933-21589132 Neighboring gene uncharacterized LOC124903872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21591626-21592452 Neighboring gene Sharpr-MPRA regulatory region 15718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21600579-21601078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21603224-21604202 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:21604203-21605179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21610131-21610992 Neighboring gene endothelin converting enzyme 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21615400-21615961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 326 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:21620661-21621860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21623064-21623668 Neighboring gene ECE1 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. Gradi A, et al. J Virol, 2003 Apr. PMID 12663812, Free PMC Article
    2. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Gingras AC, et al. Annu Rev Biochem, 1999. PMID 10872469
    3. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. Gradi A, et al. J Virol, 2004 Apr. PMID 15016848, Free PMC Article
    4. Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. Miura T, et al. J Biomol NMR, 2003 Nov. PMID 12975586
    5. Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. Wang Q, et al. Pathol Res Pract, 2019 Sep. PMID 31257089

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335.
      Title: Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants at 1p36 are associated with superior frontal gyrus volume.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA cap binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in intracellular membraneless organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 3
    Names
    eIF-4-gamma 3
    eIF-4-gamma II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047026.1 RefSeqGene

      Range
      5424..375842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198801.2 → NP_001185730.1  eukaryotic translation initiation factor 4 gamma 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
      Consensus CDS
      CCDS72723.1
      UniProtKB/TrEMBL
      A0A0A0MSA7, A0A8I5KT99
      Related
      ENSP00000383274.2, ENST00000400422.6

    2. NM_001198802.2 → NP_001185731.1  eukaryotic translation initiation factor 4 gamma 3 isoform 2

      See identical proteins and their annotated locations for NP_001185731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional in-frame smaller exon in the 5' coding region and lacks an in-frame larger exon in the middle coding region, as compared to variant 1. The resulting isoform (2) has an extra smaller segment in one region and lacks a larger segment in another region, as compared to isoform 1.
      Source sequence(s)
      AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
      Consensus CDS
      CCDS55580.1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000509941.1, ENST00000686579.1
      Conserved Domains (5) summary
      cd11559
      Location:1434 → 1562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:27 → 302
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1228 → 1340
      MA3; MA3 domain
      pfam02854
      Location:761 → 989
      MIF4G; MIF4G domain
      cl17013
      Location:1541 → 1587
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    3. NM_001198803.2 → NP_001185732.1  eukaryotic translation initiation factor 4 gamma 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR and an additional in-frame exon in the 5' coding region, and lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) has an extra internal segment and a distinct and much shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL358392, AL627311, BC030578
      Consensus CDS
      CCDS59192.1
      UniProtKB/Swiss-Prot
      O43432
      Related
      ENSP00000507819.1, ENST00000682284.1

    4. NM_001391892.1 → NP_001378821.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1428 → 1556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1222 → 1334
      MA3; MA3 domain
      pfam02854
      Location:755 → 983
      MIF4G; MIF4G domain
      cl17013
      Location:1535 → 1581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    5. NM_001391893.1 → NP_001378822.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000264211.7, ENST00000264211.13
      Conserved Domains (5) summary
      cd11559
      Location:1428 → 1556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1222 → 1334
      MA3; MA3 domain
      pfam02854
      Location:755 → 983
      MIF4G; MIF4G domain
      cl17013
      Location:1535 → 1581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    6. NM_001391894.1 → NP_001378823.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1428 → 1556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1222 → 1334
      MA3; MA3 domain
      pfam02854
      Location:755 → 983
      MIF4G; MIF4G domain
      cl17013
      Location:1535 → 1581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    7. NM_001391895.1 → NP_001378824.1  eukaryotic translation initiation factor 4 gamma 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL627311
      UniProtKB/TrEMBL
      B4DXR2

    8. NM_001391896.1 → NP_001378825.1  eukaryotic translation initiation factor 4 gamma 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1427 → 1506
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1221 → 1333
      MA3; MA3 domain
      pfam02854
      Location:754 → 982
      MIF4G; MIF4G domain
      cl17013
      Location:1484 → 1533
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    9. NM_001391897.1 → NP_001378826.1  eukaryotic translation initiation factor 4 gamma 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1379 → 1507
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam05109
      Location:107 → 322
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:1173 → 1285
      MA3; MA3 domain
      pfam02854
      Location:706 → 934
      MIF4G; MIF4G domain
      cl17013
      Location:1486 → 1532
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    10. NM_001391898.1 → NP_001378827.1  eukaryotic translation initiation factor 4 gamma 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1439 → 1518
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:4 → 307
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1233 → 1345
      MA3; MA3 domain
      pfam02854
      Location:766 → 994
      MIF4G; MIF4G domain
      cl17013
      Location:1496 → 1545
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    11. NM_001391899.1 → NP_001378828.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1427 → 1555
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1221 → 1333
      MA3; MA3 domain
      pfam02854
      Location:754 → 982
      MIF4G; MIF4G domain
      cl17013
      Location:1534 → 1580
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    12. NM_001391900.1 → NP_001378829.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000489051.2, ENST00000634879.2
      Conserved Domains (5) summary
      cd11559
      Location:1427 → 1555
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1221 → 1333
      MA3; MA3 domain
      pfam02854
      Location:754 → 982
      MIF4G; MIF4G domain
      cl17013
      Location:1534 → 1580
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    13. NM_001391901.1 → NP_001378830.1  eukaryotic translation initiation factor 4 gamma 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1435 → 1563
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:6 → 334
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:1229 → 1341
      MA3; MA3 domain
      pfam02854
      Location:762 → 990
      MIF4G; MIF4G domain
      cl17013
      Location:1542 → 1588
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    14. NM_001391902.1 → NP_001378831.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1465 → 1593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:58 → 333
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1259 → 1371
      MA3; MA3 domain
      pfam02854
      Location:792 → 1020
      MIF4G; MIF4G domain
      cl17013
      Location:1572 → 1618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    15. NM_001391903.1 → NP_001378832.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1465 → 1593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:58 → 333
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1259 → 1371
      MA3; MA3 domain
      pfam02854
      Location:792 → 1020
      MIF4G; MIF4G domain
      cl17013
      Location:1572 → 1618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    16. NM_001391904.1 → NP_001378833.1  eukaryotic translation initiation factor 4 gamma 3 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1465 → 1593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1259 → 1371
      MA3; MA3 domain
      pfam02854
      Location:792 → 1020
      MIF4G; MIF4G domain
      cl17013
      Location:1572 → 1618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    17. NM_001391905.1 → NP_001378834.1  eukaryotic translation initiation factor 4 gamma 3 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS90875.1
      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8I5QJH9
      Related
      ENSP00000509547.1, ENST00000688741.1
      Conserved Domains (5) summary
      cd11559
      Location:1476 → 1604
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1270 → 1382
      MA3; MA3 domain
      pfam02854
      Location:803 → 1031
      MIF4G; MIF4G domain
      pfam03154
      Location:53 → 368
      Atrophin-1; Atrophin-1 family
      cl17013
      Location:1583 → 1629
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    18. NM_001391906.1 → NP_001378835.1  eukaryotic translation initiation factor 4 gamma 3 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS90876.1
      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8J9G7U8
      Related
      ENSP00000473510.2, ENST00000602326.6
      Conserved Domains (5) summary
      cd11559
      Location:1484 → 1612
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:52 → 383
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:1278 → 1390
      MA3; MA3 domain
      pfam02854
      Location:811 → 1039
      MIF4G; MIF4G domain
      cl17013
      Location:1591 → 1637
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    19. NM_001391907.1 → NP_001378836.1  eukaryotic translation initiation factor 4 gamma 3 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1514 → 1642
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1308 → 1420
      MA3; MA3 domain
      pfam02854
      Location:841 → 1069
      MIF4G; MIF4G domain
      pfam03154
      Location:53 → 369
      Atrophin-1; Atrophin-1 family
      cl17013
      Location:1621 → 1667
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    20. NM_003760.4 → NP_003751.2  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      See identical proteins and their annotated locations for NP_003751.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB209119, AF012072, BC094683, BF084093
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1428 → 1556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10 → 296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1222 → 1334
      MA3; MA3 domain
      pfam02854
      Location:755 → 983
      MIF4G; MIF4G domain
      cl17013
      Location:1535 → 1581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20806292..21176897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433321.1 → XP_047289277.1  eukaryotic translation initiation factor 4 gamma 3 isoform X29

    2. XM_047433366.1 → XP_047289322.1  eukaryotic translation initiation factor 4 gamma 3 isoform X42

    3. XM_047433324.1 → XP_047289280.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

    4. XM_017002708.3 → XP_016858197.1  eukaryotic translation initiation factor 4 gamma 3 isoform X41

      UniProtKB/TrEMBL
      B4DH17
      Related
      ENSP00000364071.3, ENST00000374935.7
      Conserved Domains (4) summary
      cd11559
      Location:1148 → 1276
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:942 → 1054
      MA3; MA3 domain
      pfam02854
      Location:475 → 703
      MIF4G; MIF4G domain
      cl17013
      Location:1255 → 1301
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    5. XM_017002707.3 → XP_016858196.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

      UniProtKB/TrEMBL
      B4DZE1
      Conserved Domains (4) summary
      cd11559
      Location:1185 → 1313
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:979 → 1091
      MA3; MA3 domain
      pfam02854
      Location:512 → 740
      MIF4G; MIF4G domain
      cl17013
      Location:1292 → 1338
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    6. XM_047433340.1 → XP_047289296.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

    7. XM_011542370.3 → XP_011540672.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      See identical proteins and their annotated locations for XP_011540672.1

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1521 → 1649
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:52 → 383
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:1315 → 1427
      MA3; MA3 domain
      pfam02854
      Location:848 → 1076
      MIF4G; MIF4G domain
      cl17013
      Location:1628 → 1674
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    8. XM_047433231.1 → XP_047289187.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

      Related
      ENSP00000509442.1, ENST00000685872.1

    9. XM_047433319.1 → XP_047289275.1  eukaryotic translation initiation factor 4 gamma 3 isoform X28

      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1

    10. XM_047433196.1 → XP_047289152.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    11. XM_047433323.1 → XP_047289279.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

    12. XM_047433348.1 → XP_047289304.1  eukaryotic translation initiation factor 4 gamma 3 isoform X36

    13. XM_047433337.1 → XP_047289293.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

    14. XM_047433345.1 → XP_047289301.1  eukaryotic translation initiation factor 4 gamma 3 isoform X35

    15. XM_047433329.1 → XP_047289285.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

    16. XM_047433291.1 → XP_047289247.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

      UniProtKB/TrEMBL
      A0A0A0MSA7

    17. XM_047433287.1 → XP_047289243.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

    18. XM_047433312.1 → XP_047289268.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

      Conserved Domains (5) summary
      cd11559
      Location:1434 → 1562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:27 → 302
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1228 → 1340
      MA3; MA3 domain
      pfam02854
      Location:761 → 989
      MIF4G; MIF4G domain
      cl17013
      Location:1541 → 1587
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    19. XM_047433274.1 → XP_047289230.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

    20. XM_047433296.1 → XP_047289252.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

    21. XM_047433294.1 → XP_047289250.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

    22. XM_011542371.3 → XP_011540673.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

      See identical proteins and their annotated locations for XP_011540673.1

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1476 → 1604
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:4 → 307
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:1270 → 1382
      MA3; MA3 domain
      pfam02854
      Location:803 → 1031
      MIF4G; MIF4G domain
      cl17013
      Location:1583 → 1629
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    23. XM_047433261.1 → XP_047289217.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5
      Related
      ENSP00000507662.1, ENST00000684485.1

    24. XM_047433283.1 → XP_047289239.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

    25. XM_047433282.1 → XP_047289238.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    26. XM_017002677.3 → XP_016858166.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:1503 → 1631
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1297 → 1409
      MA3; MA3 domain
      pfam02854
      Location:830 → 1058
      MIF4G; MIF4G domain
      pfam11235
      Location:202 → 330
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      cl17013
      Location:1610 → 1656
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    27. XM_047433268.1 → XP_047289224.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

    28. XM_047433267.1 → XP_047289223.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

    29. XM_047433212.1 → XP_047289168.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

    30. XM_047433205.1 → XP_047289161.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

    31. XM_047433201.1 → XP_047289157.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

    32. XM_047433354.1 → XP_047289310.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

    33. XM_047433315.1 → XP_047289271.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

    34. XM_047433253.1 → XP_047289209.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

    35. XM_047433279.1 → XP_047289235.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

    36. XM_047433198.1 → XP_047289154.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

    37. XM_047433353.1 → XP_047289309.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

    38. XM_047433352.1 → XP_047289308.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

    39. XM_047433302.1 → XP_047289258.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

    40. XM_047433242.1 → XP_047289198.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8J9G7U8

    41. XM_047433269.1 → XP_047289225.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

    42. XM_047433266.1 → XP_047289222.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

    43. XM_047433262.1 → XP_047289218.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      20632859..21003583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339387.1 → XP_054195362.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

    2. XM_054339394.1 → XP_054195369.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

    3. XM_054339390.1 → XP_054195365.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

    4. XM_054339357.1 → XP_054195332.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    5. XM_054339361.1 → XP_054195336.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

    6. XM_054339376.1 → XP_054195351.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    7. XM_054339369.1 → XP_054195344.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

    8. XM_054339381.1 → XP_054195356.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

    9. XM_054339365.1 → XP_054195340.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5

    10. XM_054339368.1 → XP_054195343.1  eukaryotic translation initiation factor 4 gamma 3 isoform X44

      UniProtKB/TrEMBL
      A0A8I5QJH9

    11. XM_054339366.1 → XP_054195341.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

    12. XM_054339353.1 → XP_054195328.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    13. XM_054339386.1 → XP_054195361.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

    14. XM_054339389.1 → XP_054195364.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

    15. XM_054339388.1 → XP_054195363.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

    16. XM_054339379.1 → XP_054195354.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

      UniProtKB/TrEMBL
      A0A0A0MSA7

    17. XM_054339378.1 → XP_054195353.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

    18. XM_054339384.1 → XP_054195359.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

    19. XM_054339373.1 → XP_054195348.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

    20. XM_054339382.1 → XP_054195357.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

    21. XM_054339380.1 → XP_054195355.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

    22. XM_054339367.1 → XP_054195342.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

    23. XM_054339364.1 → XP_054195339.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5

    24. XM_054339377.1 → XP_054195352.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

    25. XM_054339360.1 → XP_054195335.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

    26. XM_054339375.1 → XP_054195350.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    27. XM_054339359.1 → XP_054195334.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

    28. XM_054339371.1 → XP_054195346.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

    29. XM_054339370.1 → XP_054195345.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

    30. XM_054339358.1 → XP_054195333.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

    31. XM_054339356.1 → XP_054195331.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

    32. XM_054339355.1 → XP_054195330.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

    33. XM_054339393.1 → XP_054195368.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

    34. XM_054339385.1 → XP_054195360.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

    35. XM_054339363.1 → XP_054195338.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

    36. XM_054339374.1 → XP_054195349.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

    37. XM_054339354.1 → XP_054195329.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

    38. XM_054339392.1 → XP_054195367.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

    39. XM_054339391.1 → XP_054195366.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

    40. XM_054339383.1 → XP_054195358.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

    41. XM_054339362.1 → XP_054195337.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8J9G7U8

    42. XM_054339372.1 → XP_054195347.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

    43. XM_054339352.1 → XP_054195327.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43432.2 GenPept UniProtKB/Swiss-Prot:O43432

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