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    NFIA-AS2 NFIA antisense RNA 2 [ Homo sapiens (human) ]

    Gene ID: 100996570, updated on 17-Sep-2024

    Summary

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    Official Symbol
    NFIA-AS2provided by HGNC
    Official Full Name
    NFIA antisense RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:40401
    See related
    Ensembl:ENSG00000237928 AllianceGenome:HGNC:40401
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See NFIA-AS2 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (60940244..60970740, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (60818997..60849492, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (61405916..61436412, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:61186766-61187266 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:61314805-61315635 Neighboring gene MPRA-validated peak258 silencer Neighboring gene uncharacterized LOC105378764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:61368907-61369440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:61520031-61520904 Neighboring gene Sharpr-MPRA regulatory region 5981 Neighboring gene Sharpr-MPRA regulatory region 2485 Neighboring gene NFE2L2 motif-containing MPRA enhancer 286 Neighboring gene nuclear factor I A Neighboring gene Sharpr-MPRA regulatory region 4387 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:61713056-61713264 Neighboring gene NANOG hESC enhancer GRCh37_chr1:61715889-61716390 Neighboring gene NFIA antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:61766471-61767069 Neighboring gene MPRA-validated peak260 silencer Neighboring gene Sharpr-MPRA regulatory region 1245 Neighboring gene MPRA-validated peak261 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr1:61902263-61902764 Neighboring gene VISTA enhancer hs1309 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:61942976-61943490 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:61946773-61947972 Neighboring gene uncharacterized LOC105378766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis. Xin J, et al. Hum Cell, 2020 Oct. PMID 32779154
    2. Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians. Bandesh K, et al. Int J Obes (Lond), 2023 Jun. PMID 36806387, Free PMC Article
    3. HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes. Malczewska-Lenczowska J, et al. J Strength Cond Res, 2022 Jun 1. PMID 35622109
    4. Genome-wide association study identifies three novel genetic markers associated with elite endurance performance. Ahmetov I, et al. Biol Sport, 2015 Mar. PMID 25729143, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians.
      Title: Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians.
    2. HIF-1alpha and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes.
      Title: HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes.
    3. LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis.
      Title: LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel genetic markers associated with elite endurance performance.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110617.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC096534, AL355795
      Related
      ENST00000438559.5

    2. NR_110618.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' structure and is shorter compared to variant 1.
      Source sequence(s)
      AC096534

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      60940244..60970740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      60818997..60849492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials