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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_000793.6 → NP_000784.3 type II iodothyronine deiodinase isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses a different promoter and contains two novel 5' non-coding exons; thus, has a longer 5' UTR compared to the variant 1. Variants 1 (NM_001366496.1), 2 and 3 represent the same one-Sec containing isoform (b), considered to be the canonical form.
- Source sequence(s)
-
AC007372, AF093774, AK292210, BC136514
- Related
- ENSP00000451419.1, ENST00000557010.5
-
NM_001324462.2 → NP_001311391.2 type II iodothyronine deiodinase isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses a different promoter and contains a novel 5' non-coding exon; thus, has a longer 5' UTR compared to variant 1. Variants 1 (NM_001366496.1), 2 and 3 represent the same one-Sec containing isoform (b), considered to be the canonical form.
- Source sequence(s)
-
AC007372, AF093774, BC136514, CD701270, JK546617
-
NM_001366496.1 → NP_001353425.1 type II iodothyronine deiodinase isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as hDII-a) represents the predominant transcript and encodes two isoforms resulting from the use of alternative in-frame translation termination codons. The shorter isoform (b) with one Sec residue results from translation termination at the second UGA codon, while the longer isoform (a) with two Sec residues results from translation termination at an in-frame downstream UAA stop codon. This RefSeq represents the shorter isoform (b), which is considered the canonical form as the protein extension past the second UGA codon is not conserved in orthologs from other vertebrate species. Variants 2 and 3 also represent isoform b.
- Source sequence(s)
-
AC007372, AF093774, BC136514
-
NM_013989.5 → NP_054644.1 type II iodothyronine deiodinase isoform a
See identical proteins and their annotated locations for NP_054644.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as hDII-a) represents the predominant transcript and encodes two isoforms resulting from the use of alternative in-frame translation termination codons. The shorter isoform (b) with one Sec residue results from translation termination at the second UGA codon, while the longer isoform (a) with two Sec residues results from translation termination at an in-frame downstream UAA stop codon. This RefSeq represents the longer isoform (a).
- Source sequence(s)
-
AC007372, AF093774, BC136514
- Consensus CDS
-
CCDS45146.1
- UniProtKB/Swiss-Prot
- B9EGK0, G3V315, Q6B0A3, Q92813, Q9HCP7, Q9HCP8, Q9P1W4, Q9UDZ1
- Related
- ENSP00000405854.5, ENST00000438257.9
- Conserved Domains (1) summary
-
- pfam00837
Location:4 → 262
- T4_deiodinase; Iodothyronine deiodinase
RNA
-
NR_158990.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as hDII-b) contains an internal novel exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AB041843, AC007372, AF093774, BC136514
-
NR_158991.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5, also known as hDII-c) contains two internal novel exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AB041844, AC007372, AF093774, BC136514
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000014.9 Reference GRCh38.p14 Primary Assembly
- Range
-
80197526..80231057 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060938.1 Alternate T2T-CHM13v2.0
- Range
-
74407785..74441322 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001007023.4: Suppressed sequence
- Description
- NM_001007023.4: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_001242503.2: Suppressed sequence
- Description
- NM_001242503.2: This RefSeq was removed because currently there is partial support for the transcript but none for the protein.