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    SPRY2 sprouty RTK signaling antagonist 2 [ Homo sapiens (human) ]

    Gene ID: 10253, updated on 27-Nov-2024

    Summary

    Official Symbol
    SPRY2provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 2provided by HGNC
    Primary source
    HGNC:HGNC:11270
    See related
    Ensembl:ENSG00000136158 MIM:602466; AllianceGenome:HGNC:11270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGAN3; hSPRY2
    Summary
    This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPRY2 in Genome Data Viewer
    Location:
    13q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (80335976..80341126, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (79564038..79569188, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (80910111..80915261, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:80707181-80707680 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:80721652-80721755 Neighboring gene Sharpr-MPRA regulatory region 9192 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:80763580-80764573 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:80766325-80767524 Neighboring gene uncharacterized LOC101927238 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:80792397-80792897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:80917085-80917883 Neighboring gene uncharacterized LOC105370276 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:80932978-80933742 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:80933743-80934507 Neighboring gene RNA, U6 small nuclear 61, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    IgA nephropathy, susceptibility to, 3
    MedGen: C4225194 OMIM: 616818 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
    EBI GWAS Catalog
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    EBI GWAS Catalog
    Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
    EBI GWAS Catalog
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Identification of new genetic risk variants for type 2 diabetes.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    Pr55(Gag) gag SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    gag SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics PubMed
    gag SPRY-mediated inhibition of HIV-1 Gag release is repressed by IP3R PubMed
    gag SPRY2 associates with ESCR-II component EAP20 to promote HIV-1 Gag release PubMed
    Tat tat SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    tat The expression of SPRY2 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC23039

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell projection organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of vascular endothelial growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule end IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050650.1 RefSeqGene

      Range
      4990..10140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318536.1NP_001305465.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AK313810, BC015745
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      B2R9J9, O43597, Q5T6Z7
      UniProtKB/TrEMBL
      Q7Z783
      Conserved Domains (1) summary
      pfam05210
      Location:183284
      Sprouty; Sprouty protein (Spry)
    2. NM_001318537.1NP_001305466.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AL713749, BC015745, DA230586
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      B2R9J9, O43597, Q5T6Z7
      UniProtKB/TrEMBL
      Q7Z783
      Related
      ENSP00000366306.1, ENST00000377102.5
      Conserved Domains (1) summary
      pfam05210
      Location:183284
      Sprouty; Sprouty protein (Spry)
    3. NM_001318538.1NP_001305467.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AL713749, BC015745, DA160975, DA230586
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      B2R9J9, O43597, Q5T6Z7
      UniProtKB/TrEMBL
      Q7Z783
      Conserved Domains (1) summary
      pfam05210
      Location:183284
      Sprouty; Sprouty protein (Spry)
    4. NM_005842.4NP_005833.1  protein sprouty homolog 2

      See identical proteins and their annotated locations for NP_005833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AL354668, BC015745, CX866409
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      B2R9J9, O43597, Q5T6Z7
      UniProtKB/TrEMBL
      Q7Z783
      Related
      ENSP00000366308.3, ENST00000377104.4
      Conserved Domains (1) summary
      pfam05210
      Location:183284
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      80335976..80341126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      79564038..79569188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)