FUT9 fucosyltransferase 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FUT9provided by HGNC
Official Full Name: fucosyltransferase 9provided by HGNC
Primary source: HGNC:HGNC:4020
See related: Ensembl:ENSG00000172461 MIM:606865; AllianceGenome:HGNC:4020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Fuc-TIX
Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Expression: Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q16.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (96015974..96215612)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (97186913..97387800)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (96463850..96663488)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
Title: ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
FUT9 silencing decreases the expression of the colorectal cancer TIC marker CD44 and the level of the OCT4 transcription factor, which is known to support cancer stemness.
Title: An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.
N-glycosylation of human alpha1,3-fucosyltransferase IX is required for enzyme stability and activity.
Title: N-glycosylations of human α1,3-fucosyltransferase IX are required for full enzyme activity.
FUT9 plays a significant role during human, but not mouse, E-selectin-mediated cell adhesion.
Title: Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.
Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
Title: Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
A single nucleotide polymorphism in FUT9, rs3811070, was significantly associated with placental malaria infection.
Title: A variant in the gene FUT9 is associated with susceptibility to placental malaria infection.
FUT9 was found to be a trans-Golgi and trans-Golgi network (TGN) glycosyltransferase from confocal immunofluorescence co-localization with the markers of the secretory pathway beta4-galactosyltransferase (trans-Golgi and TGN) and TGN-46 (TGN)
Title: Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization.
FUTIX plays a key role in the synthesis of Lex groups of CEACAM1
Title: CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues.
Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile
Title: Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-146306 (e-PCR)
- UniSTS:175139

SHGC-56489 (e-PCR)
- UniSTS:30505

SHGC-36057 (e-PCR)
- UniSTS:24362

SHGC-84631 (e-PCR)
- UniSTS:102955

RH27006 (e-PCR)
- UniSTS:88887

RH119421 (e-PCR)
- UniSTS:132963

SHGC-82954 (e-PCR)
- UniSTS:96113

D1S1425 (e-PCR)
- UniSTS:149621

SHGC-86200 (e-PCR)
- UniSTS:104835

SHGC-144974 (e-PCR)
- UniSTS:172493

NoName (e-PCR)
- UniSTS:480468

PMC26954P1 (e-PCR)
- UniSTS:272366

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables fucosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-fucose catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in Lewis x epitope biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-glycan fucosylation	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosphingolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuronal stem cell division	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide biosynthetic process	TAS Traceable Author Statement more info
involved_in polysaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein O-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

Names: alpha-(1,3)-fucosyltransferase 9; fucT-IX; fucosyltransferase 9 (alpha (1,3) fucosyltransferase); fucosyltransferase IX; galactoside 3-L-fucosyltransferase

NP_006572.2

EC 2.4.1.152

XP_011533687.1

EC 2.4.1.152

XP_016865677.1

EC 2.4.1.152

XP_016865679.1

EC 2.4.1.152

XP_047274044.1

EC 2.4.1.152

XP_047274045.1

EC 2.4.1.152

XP_054210029.1

EC 2.4.1.152

XP_054210030.1

EC 2.4.1.152

XP_054210031.1

EC 2.4.1.152

XP_054210032.1

EC 2.4.1.152

XP_054210033.1

EC 2.4.1.152

XP_054210034.1

EC 2.4.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006581.4 → NP_006572.2 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

See identical proteins and their annotated locations for NP_006572.2

Status: REVIEWED

Source sequence(s)

AL512406, BC036101, CK299829, CK904220

Consensus CDS

CCDS5033.1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231

Related

ENSP00000302599.4, ENST00000302103.6

Conserved Domains (2) summary

pfam00852
Location:185 → 354

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:62 → 169

Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

96015974..96215612

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418089.1 → XP_047274045.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231
XM_047418088.1 → XP_047274044.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231
XM_017010190.2 → XP_016865679.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231

Conserved Domains (2) summary

pfam00852
Location:185 → 354

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:62 → 169

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_011535385.3 → XP_011533687.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

See identical proteins and their annotated locations for XP_011533687.1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231

Conserved Domains (2) summary

pfam00852
Location:185 → 354

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:62 → 169

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_017010188.2 → XP_016865677.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/Swiss-Prot

Q5T0W4, Q9Y231

Conserved Domains (2) summary

pfam00852
Location:185 → 354

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:62 → 169

Glyco_tran_10_N; Fucosyltransferase, N-terminal

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

97186913..97387800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354058.1 → XP_054210033.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2
XM_054354056.1 → XP_054210031.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2
XM_054354059.1 → XP_054210034.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2
XM_054354057.1 → XP_054210032.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2
XM_054354054.1 → XP_054210029.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2
XM_054354055.1 → XP_054210030.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

UniProtKB/TrEMBL

Q5Q0U2