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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001319676.2 → NP_001306605.1 calpain-9 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks two alternate coding exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
- Source sequence(s)
-
AB038463, AF022799, AK298024, AL512328
- Consensus CDS
-
CCDS81431.1
- UniProtKB/TrEMBL
- E7ESS6, Q6PIV8
- Related
- ENSP00000355626.2, ENST00000366666.6
- Conserved Domains (5) summary
-
- cd00051
Location:503 → 558
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 272
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:286 → 428
- Calpain_III; Calpain large subunit, domain III
- pfam13499
Location:535 → 589
- EF-hand_7; EF-hand domain pair
- cl08302
Location:537 → 589
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
NM_006615.3 → NP_006606.1 calpain-9 isoform 1
See identical proteins and their annotated locations for NP_006606.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AF022799, AL512328, BC027993
- Consensus CDS
-
CCDS1586.1
- UniProtKB/Swiss-Prot
- B1APS1, B1AQI0, O14815, Q9NS74
- UniProtKB/TrEMBL
-
B2R942
- Related
- ENSP00000271971.2, ENST00000271971.7
- Conserved Domains (5) summary
-
- PTZ00184
Location:514 → 657
- PTZ00184; calmodulin; Provisional
- cd00051
Location:566 → 621
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 335
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:349 → 491
- Calpain_III; Calpain large subunit, domain III
- cl08302
Location:600 → 652
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
NM_016452.3 → NP_057536.1 calpain-9 isoform 2
See identical proteins and their annotated locations for NP_057536.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
- Source sequence(s)
-
AB038463, AF022799, AL512328
- Consensus CDS
-
CCDS31053.1
- UniProtKB/TrEMBL
-
B2R942
- Related
- ENSP00000346538.1, ENST00000354537.1
- Conserved Domains (5) summary
-
- PTZ00184
Location:488 → 631
- PTZ00184; calmodulin; Provisional
- cd00051
Location:540 → 595
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 309
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:323 → 465
- Calpain_III; Calpain large subunit, domain III
- cl08302
Location:574 → 626
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
230747388..230801989
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011544017.2 → XP_011542319.1 calpain-9 isoform X1
- UniProtKB/TrEMBL
-
B2R942
- Conserved Domains (5) summary
-
- PTZ00184
Location:514 → 657
- PTZ00184; calmodulin; Provisional
- cd00051
Location:566 → 621
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 335
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:349 → 491
- Calpain_III; Calpain large subunit, domain III
- cl08302
Location:600 → 652
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
XM_011544018.2 → XP_011542320.1 calpain-9 isoform X2
- UniProtKB/TrEMBL
-
B2R942
- Conserved Domains (5) summary
-
- PTZ00184
Location:488 → 631
- PTZ00184; calmodulin; Provisional
- cd00051
Location:540 → 595
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 309
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:323 → 465
- Calpain_III; Calpain large subunit, domain III
- cl08302
Location:574 → 626
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
XM_017000098.2 → XP_016855587.1 calpain-9 isoform X3
- UniProtKB/TrEMBL
-
B2R942
-
XM_011544019.3 → XP_011542321.1 calpain-9 isoform X4
- UniProtKB/TrEMBL
-
Q6PIV8
- Conserved Domains (5) summary
-
- PTZ00184
Location:451 → 594
- PTZ00184; calmodulin; Provisional
- cd00051
Location:503 → 558
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- pfam00648
Location:43 → 272
- Peptidase_C2; Calpain family cysteine protease
- pfam01067
Location:286 → 428
- Calpain_III; Calpain large subunit, domain III
- cl08302
Location:537 → 589
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
XM_047439807.1 → XP_047295763.1 calpain-9 isoform X5
-
XM_047439808.1 → XP_047295764.1 calpain-9 isoform X6
-
XM_024452513.2 → XP_024308281.1 calpain-9 isoform X7
- Conserved Domains (4) summary
-
- cd00214
Location:29 → 178
- Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
- cd15897
Location:204 → 232
- EFh_PEF; EF-hand motif [structural motif]
- cl00051
Location:1 → 26
- CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
- cl25352
Location:204 → 344
- EFh_PEF; The penta-EF hand (PEF) family
-
XM_024452514.2 → XP_024308282.1 calpain-9 isoform X7
- Conserved Domains (4) summary
-
- cd00214
Location:29 → 178
- Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
- cd15897
Location:204 → 232
- EFh_PEF; EF-hand motif [structural motif]
- cl00051
Location:1 → 26
- CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
- cl25352
Location:204 → 344
- EFh_PEF; The penta-EF hand (PEF) family
RNA
-
XR_949127.2 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
230127941..230182452
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054333927.1 → XP_054189902.1 calpain-9 isoform X1
- UniProtKB/TrEMBL
-
B2R942
-
XM_054333928.1 → XP_054189903.1 calpain-9 isoform X2
- UniProtKB/TrEMBL
-
B2R942
-
XM_054333929.1 → XP_054189904.1 calpain-9 isoform X3
- UniProtKB/TrEMBL
-
B2R942
-
XM_054333931.1 → XP_054189906.1 calpain-9 isoform X4
- UniProtKB/TrEMBL
-
Q6PIV8
-
XM_054333932.1 → XP_054189907.1 calpain-9 isoform X5
-
XM_054333930.1 → XP_054189905.1 calpain-9 isoform X8
- UniProtKB/TrEMBL
-
B2R942
-
XM_054333933.1 → XP_054189908.1 calpain-9 isoform X7
-
XM_054333934.1 → XP_054189909.1 calpain-9 isoform X7
RNA
-
XR_008485878.1 RNA Sequence