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    GLOD4 glyoxalase domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 51031, updated on 3-Dec-2024

    Summary

    Official Symbol
    GLOD4provided by HGNC
    Official Full Name
    glyoxalase domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:14111
    See related
    Ensembl:ENSG00000167699 MIM:620650; AllianceGenome:HGNC:14111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HC6; HC71; CGI-150; C17orf25
    Summary
    Enables cadherin binding activity. Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 28.9), duodenum (RPKM 28.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GLOD4 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (759330..785895, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (644616..672323, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (662570..685520, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7945 Neighboring gene TLC domain containing 3A Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11440 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:685572-686120 Neighboring gene Sharpr-MPRA regulatory region 8532 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11442 Neighboring gene nucleoredoxin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:736782-737522 Neighboring gene Sharpr-MPRA regulatory region 9814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:746053-747038 Neighboring gene uncharacterized LOC124903894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:753668-754242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:754898-755398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:773909-774736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:790499-790998 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:800010-801209 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:801761-802401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:802905-803406 Neighboring gene uncharacterized LOC101927727 Neighboring gene Sharpr-MPRA regulatory region 13189

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    glyoxalase domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366247.2NP_001353176.1  glyoxalase domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087392
      Consensus CDS
      CCDS92216.1
      UniProtKB/Swiss-Prot
      D3DTG9, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9HC38, Q9NVN1
      UniProtKB/TrEMBL
      A8K8F0
      Related
      ENSP00000301328.5, ENST00000301328.9
      Conserved Domains (2) summary
      cd16357
      Location:155270
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:4145
      VOC; vicinal oxygen chelate (VOC) family
    2. NM_001366248.2NP_001353177.1  glyoxalase domain-containing protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B3KV49
      Conserved Domains (2) summary
      cd16357
      Location:84199
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:174
      VOC; vicinal oxygen chelate (VOC) family
    3. NM_001366249.2NP_001353178.1  glyoxalase domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B7Z403
      Conserved Domains (2) summary
      cd16357
      Location:131246
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:39121
      VOC; vicinal oxygen chelate (VOC) family
    4. NM_001366250.2NP_001353179.1  glyoxalase domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B7Z403
      Conserved Domains (2) summary
      cd16357
      Location:131246
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:39121
      VOC; vicinal oxygen chelate (VOC) family
    5. NM_001389725.1NP_001376654.1  glyoxalase domain-containing protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087392
      Conserved Domains (2) summary
      cd16357
      Location:206321
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:4196
      VOC; vicinal oxygen chelate (VOC) family
    6. NM_001389726.1NP_001376655.1  glyoxalase domain-containing protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd16357
      Location:177292
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:4167
      VOC; vicinal oxygen chelate (VOC) family
    7. NM_001389727.1NP_001376656.1  glyoxalase domain-containing protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140255
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    8. NM_001389728.1NP_001376657.1  glyoxalase domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B7Z403
      Conserved Domains (2) summary
      cd16357
      Location:131246
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:39121
      VOC; vicinal oxygen chelate (VOC) family
    9. NM_001389729.1NP_001376658.1  glyoxalase domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B7Z403
      Conserved Domains (2) summary
      cd16357
      Location:131246
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:39121
      VOC; vicinal oxygen chelate (VOC) family
    10. NM_001389730.1NP_001376659.1  glyoxalase domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0, B7Z403
      Conserved Domains (2) summary
      cd16357
      Location:131246
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:39121
      VOC; vicinal oxygen chelate (VOC) family
    11. NM_001389731.1NP_001376660.1  glyoxalase domain-containing protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140242
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    12. NM_001389732.1NP_001376661.1  glyoxalase domain-containing protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140248
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    13. NM_001389733.1NP_001376662.1  glyoxalase domain-containing protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140236
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    14. NM_001389734.1NP_001376663.1  glyoxalase domain-containing protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      A8K8F0
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140226
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    15. NM_001389735.1NP_001376664.1  glyoxalase domain-containing protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      I3L3Q4
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:140217
      VOC; vicinal oxygen chelate (VOC) family
    16. NM_001389736.1NP_001376665.1  glyoxalase domain-containing protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC087392
      UniProtKB/TrEMBL
      I3L3Q4
      Related
      ENSP00000460634.1, ENST00000576419.1
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:140210
      VOC; vicinal oxygen chelate (VOC) family
    17. NM_016080.4NP_057164.3  glyoxalase domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_057164.3

      Status: VALIDATED

      Source sequence(s)
      AF061730, BC008605, DA608953
      Consensus CDS
      CCDS32520.1
      UniProtKB/TrEMBL
      A8K8F0
      Related
      ENSP00000301329.6, ENST00000301329.11
      Conserved Domains (2) summary
      cd08358
      Location:4130
      GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cd16357
      Location:140255
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      759330..785895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436196.1XP_047292152.1  glyoxalase domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K8F0, B3KV49

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      644616..672323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316341.1XP_054172316.1  glyoxalase domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K8F0, B3KV49