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    PPIE peptidylprolyl isomerase E [ Homo sapiens (human) ]

    Gene ID: 10450, updated on 3-Dec-2024

    Summary

    Official Symbol
    PPIEprovided by HGNC
    Official Full Name
    peptidylprolyl isomerase Eprovided by HGNC
    Primary source
    HGNC:HGNC:9258
    See related
    Ensembl:ENSG00000084072 MIM:602435; AllianceGenome:HGNC:9258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CypE; CYP33; CYP-33
    Summary
    The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPIE in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (39738882..39763914)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39608324..39633355)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40204554..40229586)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 25 pseudogene Neighboring gene RNA, U7 small nuclear 121 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 816 Neighboring gene bone morphogenetic protein 8b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40236393-40237066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40237067-40237739 Neighboring gene 3-oxoacid CoA-transferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40244416-40244916 Neighboring gene BMP8B antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular peptidylprolyl isomerase E protein (PPIE, cyclophilin E) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3736, MGC111222

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase E
    Names
    PPIase E
    cyclophilin-33
    peptidylprolyl isomerase E (cyclophilin E)
    rotamase E
    NP_001181936.1
    NP_001306222.1
    NP_006103.1
    NP_982281.1
    XP_006710353.1
    XP_016855540.1
    XP_047286017.1
    XP_047286054.1
    XP_047286094.1
    XP_047286120.1
    XP_047286159.1
    XP_054189805.1
    XP_054189806.1
    XP_054189807.1
    XP_054189808.1
    XP_054189809.1
    XP_054189810.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_044984.2 RefSeqGene

      Range
      51701..76733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1053

    mRNA and Protein(s)

    1. NM_001195007.2NP_001181936.1  peptidyl-prolyl cis-trans isomerase E isoform 4

      See identical proteins and their annotated locations for NP_001181936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AL049824, BU689929, DA079924, DQ160195
      Consensus CDS
      CCDS53299.1
      UniProtKB/TrEMBL
      A8KAM9
      Related
      ENSP00000361918.1, ENST00000372830.5
      Conserved Domains (3) summary
      COG0724
      Location:584
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01926
      Location:140279
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:880
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    2. NM_001319293.2NP_001306222.1  peptidyl-prolyl cis-trans isomerase E isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CA445146, CT002466, DA079924
      UniProtKB/TrEMBL
      A8KAM9
      Conserved Domains (3) summary
      COG0724
      Location:584
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01926
      Location:129268
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:880
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    3. NM_006112.4NP_006103.1  peptidyl-prolyl cis-trans isomerase E isoform 1

      See identical proteins and their annotated locations for NP_006103.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AL049824, BC004898, CK300365, DA079924
      Consensus CDS
      CCDS443.1
      UniProtKB/Swiss-Prot
      B2R971, O43634, O43635, Q32Q72, Q3S611, Q5TGA0, Q5TGA2, Q5TGA3, Q9UIZ5, Q9UNP9
      UniProtKB/TrEMBL
      A8KAM9
      Related
      ENSP00000312769.5, ENST00000324379.10
      Conserved Domains (2) summary
      cd01926
      Location:140298
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
      cd12347
      Location:882
      RRM_PPIE; RNA recognition motif (RRM) found in cyclophilin-33 (Cyp33) and similar proteins
    4. NM_203456.3NP_982281.1  peptidyl-prolyl cis-trans isomerase E isoform 2

      See identical proteins and their annotated locations for NP_982281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' exon and thereby differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AF042386, BU689929, DA079924
      Consensus CDS
      CCDS442.1
      UniProtKB/TrEMBL
      A8KAM9
      Related
      ENSP00000348904.2, ENST00000356511.6
      Conserved Domains (2) summary
      cd01926
      Location:140281
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
      cd12347
      Location:882
      RRM_PPIE; RNA recognition motif (RRM) found in cyclophilin-33 (Cyp33) and similar proteins

    RNA

    1. NR_036543.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5'-most exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL049824, BU160972, CK300365, DA079924
    2. NR_036544.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses alternate splice sites in the 5'-most exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK304694, AL049824, CK300365, DA079924

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      39738882..39763914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430138.1XP_047286094.1  peptidyl-prolyl cis-trans isomerase E isoform X4

      UniProtKB/TrEMBL
      E9PKY5
      Related
      ENSP00000433475.1, ENST00000497370.5
    2. XM_017000051.3XP_016855540.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      UniProtKB/TrEMBL
      A8KAM9
      Conserved Domains (3) summary
      COG0724
      Location:584
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01926
      Location:140279
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:880
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    3. XM_047430061.1XP_047286017.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      UniProtKB/TrEMBL
      A8KAM9
    4. XM_047430098.1XP_047286054.1  peptidyl-prolyl cis-trans isomerase E isoform X2

      UniProtKB/TrEMBL
      A8KAM9
    5. XM_006710290.5XP_006710353.1  peptidyl-prolyl cis-trans isomerase E isoform X3

      See identical proteins and their annotated locations for XP_006710353.1

      UniProtKB/TrEMBL
      A8KAM9
      Conserved Domains (2) summary
      cd01926
      Location:129285
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:880
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    6. XM_047430203.1XP_047286159.1  peptidyl-prolyl cis-trans isomerase E isoform X6

      UniProtKB/TrEMBL
      E9PK21
      Related
      ENSP00000431714.1, ENST00000470213.5
    7. XM_047430164.1XP_047286120.1  peptidyl-prolyl cis-trans isomerase E isoform X5

      UniProtKB/TrEMBL
      E9PKY5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      39608324..39633355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333831.1XP_054189806.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      UniProtKB/TrEMBL
      A8KAM9
    2. XM_054333830.1XP_054189805.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      UniProtKB/TrEMBL
      A8KAM9
    3. XM_054333832.1XP_054189807.1  peptidyl-prolyl cis-trans isomerase E isoform X2

      UniProtKB/TrEMBL
      A8KAM9
    4. XM_054333833.1XP_054189808.1  peptidyl-prolyl cis-trans isomerase E isoform X3

      UniProtKB/TrEMBL
      A8KAM9
    5. XM_054333835.1XP_054189810.1  peptidyl-prolyl cis-trans isomerase E isoform X6

      UniProtKB/TrEMBL
      E9PK21
    6. XM_054333834.1XP_054189809.1  peptidyl-prolyl cis-trans isomerase E isoform X5

      UniProtKB/TrEMBL
      E9PKY5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203457.1: Suppressed sequence

      Description
      NM_203457.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.