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    RNF24 ring finger protein 24 [ Homo sapiens (human) ]

    Gene ID: 11237, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RNF24provided by HGNC
    Official Full Name
    ring finger protein 24provided by HGNC
    Primary source
    HGNC:HGNC:13779
    See related
    Ensembl:ENSG00000101236 MIM:612489; AllianceGenome:HGNC:13779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G1L
    Summary
    This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 12.4), brain (RPKM 5.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF24 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3927311..4015558, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3958229..4046504, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3907958..3996205, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3869109-3869660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12635 Neighboring gene PANK2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17488 Neighboring gene pantothenate kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3886163-3886663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17489 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60114 Neighboring gene microRNA 103b-2 Neighboring gene microRNA 103a-2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3996195-3997127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3997331-3997932 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4014121-4014765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17491 Neighboring gene ferritin light chain pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4026722-4027222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4027223-4027723 Neighboring gene ribosomal protein L21 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Lussier MP, et al. Cell Calcium, 2008 May. PMID 17850865
    2. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
    4. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134337.3 → NP_001127809.1  RING finger protein 24 isoform 1

      See identical proteins and their annotated locations for NP_001127809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AL031670, BC039584, BQ181223, CD367454, HY140488
      Consensus CDS
      CCDS13074.1
      UniProtKB/Swiss-Prot
      D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
      Related
      ENSP00000351166.6, ENST00000358395.11
      Conserved Domains (1) summary
      cd16469
      Location:76 → 122
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    2. NM_001134338.3 → NP_001127810.1  RING finger protein 24 isoform 2

      See identical proteins and their annotated locations for NP_001127810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different segment for its 5' UTR and includes an alternate segment which uses an upstream AUG codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AL031670, BC000213, BQ181223, CD367454, HY140488
      Consensus CDS
      CCDS46577.1
      UniProtKB/Swiss-Prot
      Q9Y225
      Related
      ENSP00000444711.1, ENST00000545616.2
      Conserved Domains (1) summary
      cd16469
      Location:97 → 143
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    3. NM_001321749.2 → NP_001308678.1  RING finger protein 24 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AL031670, BQ181223, HY050527, HY140488
      Consensus CDS
      CCDS13074.1
      UniProtKB/Swiss-Prot
      D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
      Conserved Domains (1) summary
      cd16469
      Location:76 → 122
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    4. NM_007219.5 → NP_009150.1  RING finger protein 24 isoform 1

      See identical proteins and their annotated locations for NP_009150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript yet it encodes the shorter isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AL031670, AL096778, BQ181223, CD367454, HY050527, HY140488
      Consensus CDS
      CCDS13074.1
      UniProtKB/Swiss-Prot
      D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
      Related
      ENSP00000336753.5, ENST00000336095.10
      Conserved Domains (1) summary
      cd16469
      Location:76 → 122
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3927311..4015558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529146.3 → XP_011527448.1  RING finger protein 24 isoform X2

      Conserved Domains (1) summary
      cd16469
      Location:91 → 137
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    2. XM_017027621.2 → XP_016883110.1  RING finger protein 24 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y225
      Conserved Domains (1) summary
      cd16469
      Location:97 → 143
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    3. XM_017027620.2 → XP_016883109.1  RING finger protein 24 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y225
      Conserved Domains (1) summary
      cd16469
      Location:97 → 143
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    4. XM_047439866.1 → XP_047295822.1  RING finger protein 24 isoform X1

    5. XM_047439865.1 → XP_047295821.1  RING finger protein 24 isoform X1

      Related
      ENSP00000388550.2, ENST00000432261.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3958229..4046504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322915.1 → XP_054178890.1  RING finger protein 24 isoform X2

    2. XM_054322911.1 → XP_054178886.1  RING finger protein 24 isoform X1

    3. XM_054322912.1 → XP_054178887.1  RING finger protein 24 isoform X1

    4. XM_054322914.1 → XP_054178889.1  RING finger protein 24 isoform X1

    5. XM_054322913.1 → XP_054178888.1  RING finger protein 24 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016502.1: Suppressed sequence

      Description
      NM_016502.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y225.1 GenPept UniProtKB/Swiss-Prot:Q9Y225

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