SMARCA4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SMARCA4provided by HGNC
Official Full Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4provided by HGNC
Primary source: HGNC:HGNC:11100
See related: Ensembl:ENSG00000127616 MIM:603254; AllianceGenome:HGNC:11100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; OTSC12; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression: Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10961030..11062273)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (11088037..11189277)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (11071706..11172949)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review.
Title: SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review.
Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians.
Title: Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians.
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing.
Title: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing.
BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription.
Title: BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription.
BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
Title: BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer.
Title: SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer.
SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
Title: SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases.
Title: Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases.
ATP-dependent chromatin remodeller brahma related gene 1 promotes keratinocyte migration and modulates cell Signalling during wound healing in human skin.
Title: ATP-dependent chromatin remodeller brahma related gene 1 promotes keratinocyte migration and modulates cell Signalling during wound healing in human skin.
Rare SMARCA4-deficient thoracic tumor: Insights into molecular characterization and optimal therapeutics methods.
Title: Rare SMARCA4-deficient thoracic tumor: Insights into molecular characterization and optimal therapeutics methods.

Submit: New GeneRIF Correction See all GeneRIFs (379)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, autosomal dominant 16 MedGen: C3553249 OMIM: 614609 GeneReviews: Not available	Compare labs
Rhabdoid tumor predisposition syndrome 2 MedGen: C2750074 OMIM: 613325 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2024-07-24) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2024-07-24) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Most of the components of the SWI2/SNF2 chromatin remodeling complex (BRG1/BRM, BAF250, BAF180, BAF170, BAF155, BAF60a, BAF53A, actin and InI) except BRM, BAF155 and BAF57, are identified to interact with HIV-1 Tat in Jurkat cell	PubMed
	tat	HIV-1 Tat induces phosphorylation of BRG1 and BAF155	PubMed
	tat	INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins	PubMed
	tat	Acetylated HIV-1 Tat binds efficiently to BRG1 and BAF200 (component of PBAF complex) and weakly to BAF250 (component of BAF complex)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S991 (e-PCR)
- UniSTS:8487

Smarca4 (e-PCR), detects polymorphism
- UniSTS:265811

WI-18794 (e-PCR)
- UniSTS:15008

SHGC-144512 (e-PCR)
- UniSTS:183201

D19S1111 (e-PCR)
- UniSTS:81403

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IGI Inferred from Genetic Interaction more info	PubMed
enables ATP-dependent chromatin remodeler activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase I core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables Tat protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to nucleosomal DNA binding	HDA more info	PubMed
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	HDA more info	PubMed
involved_in chromatin remodeling	IC Inferred by Curator more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleosome disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation by host of viral transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of glucose mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of GBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	NAS Non-traceable Author Statement more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	HDA more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	HDA more info	PubMed
part_of nBAF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of npBAF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	HDA more info	PubMed

General protein information

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Preferred Names: transcription activator BRG1

Names: ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BRM/SWI2-related gene 1; SNF2-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; brahma protein-like 1; global transcription activator homologous sequence; homeotic gene regulator; mitotic growth and transcription activator; nuclear protein GRB1; protein BRG-1; protein brahma homolog 1; sucrose nonfermenting-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011556.3 RefSeqGene

Range

5099..106342

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_878

mRNA and Protein(s)

NM_001128844.3 → NP_001122316.1 transcription activator BRG1 isoform B

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS12253.1

UniProtKB/Swiss-Prot

B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3

UniProtKB/TrEMBL

A7E2E1, B9EGQ8

Related

ENSP00000395654.1, ENST00000429416.8

Conserved Domains (9) summary

cd05516
Location:1458 → 1564

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001128845.2 → NP_001122317.1 transcription activator BRG1 isoform C

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS45972.1

UniProtKB/TrEMBL

B9EGQ8

Related

ENSP00000496635.1, ENST00000643296.1

Conserved Domains (9) summary

cd05516
Location:1428 → 1534

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001128846.2 → NP_001122318.1 transcription activator BRG1 isoform D

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS45973.1

UniProtKB/TrEMBL

B9EGQ8

Related

ENSP00000464778.1, ENST00000589677.5

Conserved Domains (9) summary

cd05516
Location:1428 → 1533

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001128847.4 → NP_001122319.1 transcription activator BRG1 isoform E

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS54217.1

UniProtKB/TrEMBL

B9EGQ8

Related

ENSP00000494676.1, ENST00000647230.1

Conserved Domains (9) summary

cd05516
Location:1425 → 1531

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1290 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001128848.2 → NP_001122320.1 transcription activator BRG1 isoform F

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS54218.1

UniProtKB/TrEMBL

B9EGQ8

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001128849.3 → NP_001122321.1 transcription activator BRG1 isoform A

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

UniProtKB/TrEMBL

B9EGQ8, Q9HBD4

Related

ENSP00000518564.1, ENST00000711079.1

Conserved Domains (9) summary

cd05516
Location:1490 → 1596

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001374457.1 → NP_001361386.1 transcription activator BRG1 isoform E

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS54217.1

UniProtKB/TrEMBL

B9EGQ8

Related

ENSP00000495536.1, ENST00000646484.1

Conserved Domains (9) summary

cd05516
Location:1425 → 1531

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1290 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001387283.1 → NP_001374212.1 transcription activator BRG1 isoform A

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

UniProtKB/TrEMBL

B9EGQ8, Q9HBD4

Related

ENSP00000495368.1, ENST00000646693.2

Conserved Domains (9) summary

cd05516
Location:1490 → 1596

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
NM_001411150.1 → NP_001398079.1 transcription activator BRG1 isoform G

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS92517.1

UniProtKB/TrEMBL

A0A2R8Y7S2

Related

ENSP00000494353.1, ENST00000642726.1
NM_003072.5 → NP_003063.2 transcription activator BRG1 isoform B

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

Consensus CDS

CCDS12253.1

UniProtKB/Swiss-Prot

B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3

UniProtKB/TrEMBL

A7E2E1, B9EGQ8

Related

ENSP00000343896.4, ENST00000344626.10

Conserved Domains (9) summary

cd05516
Location:1458 → 1564

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex

RNA

NR_164683.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC006127, AC011442, AC011485

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

10961030..11062273

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528198.2 → XP_011526500.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

B9EGQ8, Q9HBD4

Conserved Domains (9) summary

cd05516
Location:1490 → 1596

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_047439249.1 → XP_047295205.1 transcription activator BRG1 isoform X6

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_024451658.2 → XP_024307426.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

B9EGQ8, Q9HBD4

Conserved Domains (9) summary

cd05516
Location:1490 → 1596

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_047439247.1 → XP_047295203.1 transcription activator BRG1 isoform X5

Related

ENSP00000494772.1, ENST00000646510.1
XM_024451661.2 → XP_024307429.1 transcription activator BRG1 isoform X3

UniProtKB/TrEMBL

A0A2R8Y7S2, B9EGQ8

Related

ENSP00000496498.1, ENST00000642628.1

Conserved Domains (9) summary

cd05516
Location:1457 → 1563

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1290 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_024451663.2 → XP_024307431.1 transcription activator BRG1 isoform X4

UniProtKB/TrEMBL

B9EGQ8

Conserved Domains (8) summary

cd05516
Location:1457 → 1562

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

pfam08880
Location:171 → 205

QLQ; QLQ

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl25732
Location:370 → 552

SMC_N; RecF/RecN/SMC N terminal domain

cl26465
Location:750 → 1232

SNF2_N; SNF2 family N-terminal domain
XM_024451667.2 → XP_024307435.1 transcription activator BRG1 isoform X6

UniProtKB/TrEMBL

B9EGQ8

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_047439244.1 → XP_047295200.1 transcription activator BRG1 isoform X2

UniProtKB/Swiss-Prot

B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3

UniProtKB/TrEMBL

A7E2E1

Related

ENSP00000515855.1, ENST00000704344.1
XM_047439246.1 → XP_047295202.1 transcription activator BRG1 isoform X4
XM_047439250.1 → XP_047295206.1 transcription activator BRG1 isoform X6

Related

ENSP00000494463.1, ENST00000645460.1

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_047439243.1 → XP_047295199.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

Q9HBD4
XM_006722846.3 → XP_006722909.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

B9EGQ8, Q9HBD4

Conserved Domains (9) summary

cd05516
Location:1490 → 1596

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam07533
Location:612 → 654

BRK; BRK domain

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1323 → 1389

SnAC; Snf2-ATP coupling, chromatin remodelling complex
XM_047439248.1 → XP_047295204.1 transcription activator BRG1 isoform X5

Related

ENSP00000466963.1, ENST00000590574.6
XM_047439251.1 → XP_047295207.1 transcription activator BRG1 isoform X6

Conserved Domains (9) summary

cd05516
Location:1425 → 1530

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:612 → 656

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:460 → 532

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:750 → 1232

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

COG1196
Location:370 → 552

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09606
Location:42 → 222

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18062
Location:731 → 981

DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4

pfam08880
Location:171 → 205

QLQ

pfam14619
Location:1289 → 1356

SnAC; Snf2-ATP coupling, chromatin remodelling complex

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

11088037..11189277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321813.1 → XP_054177788.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

Q9HBD4
XM_054321823.1 → XP_054177798.1 transcription activator BRG1 isoform X6
XM_054321814.1 → XP_054177789.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

Q9HBD4
XM_054321821.1 → XP_054177796.1 transcription activator BRG1 isoform X5
XM_054321818.1 → XP_054177793.1 transcription activator BRG1 isoform X3

UniProtKB/TrEMBL

A0A2R8Y7S2
XM_054321819.1 → XP_054177794.1 transcription activator BRG1 isoform X4
XM_054321824.1 → XP_054177799.1 transcription activator BRG1 isoform X6
XM_054321817.1 → XP_054177792.1 transcription activator BRG1 isoform X2

UniProtKB/Swiss-Prot

B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3

UniProtKB/TrEMBL

A7E2E1
XM_054321820.1 → XP_054177795.1 transcription activator BRG1 isoform X4
XM_054321825.1 → XP_054177800.1 transcription activator BRG1 isoform X6
XM_054321816.1 → XP_054177791.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

Q9HBD4
XM_054321815.1 → XP_054177790.1 transcription activator BRG1 isoform X1

UniProtKB/TrEMBL

Q9HBD4
XM_054321826.1 → XP_054177801.1 transcription activator BRG1 isoform X6
XM_054321822.1 → XP_054177797.1 transcription activator BRG1 isoform X5