U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PGBD5 piggyBac transposable element derived 5 [ Homo sapiens (human) ]

    Gene ID: 79605, updated on 27-Nov-2024

    Summary

    Official Symbol
    PGBD5provided by HGNC
    Official Full Name
    piggyBac transposable element derived 5provided by HGNC
    Primary source
    HGNC:HGNC:19405
    See related
    Ensembl:ENSG00000177614 MIM:616791; AllianceGenome:HGNC:19405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, May 2010]
    Expression
    Biased expression in brain (RPKM 13.1), adrenal (RPKM 4.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PGBD5 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (230314490..230426332, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (229693950..229806671, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (230450236..230562078, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2709 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:230207245-230207425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230220010-230220551 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:230240174-230241373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230247432-230248098 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:230248997-230250196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2715 Neighboring gene Sharpr-MPRA regulatory region 12256 Neighboring gene Sharpr-MPRA regulatory region 1224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230273165-230273665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230272664-230273164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230276043-230276635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2716 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:230311720-230311947 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:230321452-230322190 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:230322191-230322929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230334008-230334701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230336117-230336616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230361793-230362294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230362295-230362794 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230387089-230387750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230387751-230388411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230390520-230391020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230391021-230391521 Neighboring gene uncharacterized LOC124904542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230400862-230401362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230401363-230401863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230402952-230403462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230403463-230403971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230403972-230404481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230404482-230404990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230422195-230422694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230423879-230424378 Neighboring gene NANOG hESC enhancer GRCh37_chr1:230431082-230431583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1939 Neighboring gene putative uncharacterized protein FLJ46204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230452427-230452928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230452929-230453428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2718 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:230468147-230468791 and GRCh37_chr1:230468792-230469436 Neighboring gene uncharacterized LOC124904543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230535746-230536379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230562153-230562700 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:230562701-230563247 Neighboring gene uncharacterized LOC105373164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:230653241-230653776 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:230654311-230654846 Neighboring gene uncharacterized LOC105373165

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11413, DKFZp761A0620

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transposase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transposase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transposase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in non-replicative DNA transposition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-replicative DNA transposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    piggyBac transposable element-derived protein 5
    Names
    piggyBac domain related protein 5
    piggyBac transposase 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258311.2NP_001245240.1  piggyBac transposable element-derived protein 5

      See identical proteins and their annotated locations for NP_001245240.1

      Status: REVIEWED

      Source sequence(s)
      AL133516, AL691479, BC013901, BC036865, CX757968
      Consensus CDS
      CCDS81430.1
      UniProtKB/Swiss-Prot
      A0A0A0MS21, A0PJF3, B4DM72, B7Z9K3, B9EK58, Q5SR37, Q6PJN2, Q8N414, U3REJ1
      Related
      ENSP00000375733.2, ENST00000391860.7
      Conserved Domains (1) summary
      pfam13843
      Location:121487
      DDE_Tnp_1_7; Transposase IS4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      230314490..230426332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      229693950..229806671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024554.3: Suppressed sequence

      Description
      NM_024554.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.