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    ZNF3 zinc finger protein 3 [ Homo sapiens (human) ]

    Gene ID: 7551, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF3provided by HGNC
    Official Full Name
    zinc finger protein 3provided by HGNC
    Primary source
    HGNC:HGNC:13089
    See related
    Ensembl:ENSG00000166526 MIM:194510; AllianceGenome:HGNC:13089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A8-51; HF.12; KOX25; PP838; Zfp113
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 7.6), thyroid (RPKM 6.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF3 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100063837..100082577, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101303346..101322424, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99661460..99680200, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26332 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99601306-99601806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99604826-99605326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99605327-99605827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99607545-99608044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18412 Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99634953-99635454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99635455-99635954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99647299-99647918 Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26333 Neighboring gene Sharpr-MPRA regulatory region 7718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26334 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99679591-99680572 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99684712-99685405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18414 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:99686990-99688189 Neighboring gene Sharpr-MPRA regulatory region 1952 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 25 Neighboring gene minichromosome maintenance complex component 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer. Du L, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Dec 25. PMID 36789689, Free PMC Article
    2. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. Pannuti A, et al. Nucleic Acids Res, 1988 May 25. PMID 3380682, Free PMC Article
    3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. Rosati M, et al. Nucleic Acids Res, 1991 Oct 25. PMID 1945843, Free PMC Article
    4. Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1. Dumoulin B, et al. Biochim Biophys Acta Gen Subj, 2020 Nov. PMID 32645484
    5. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer.
      Title: ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer.
    2. ZNF3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
      Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 3
    Names
    C2-H2 type zinc finger protein
    zinc finger protein HF.12
    zinc finger protein HZF3.1
    zinc finger protein KOX25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278284.2 → NP_001265213.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 2. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
      Source sequence(s)
      AC073842, BC041695, CA439866
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001278287.2 → NP_001265216.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
      Source sequence(s)
      AC073842, BC041695, BQ071498, CA439866
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001278290.2 → NP_001265219.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
      Source sequence(s)
      BC041695, CA439866, HY096067
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Related
      ENSP00000415358.1, ENST00000424697.5
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001278291.2 → NP_001265220.1  zinc finger protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks the exon containing the translation start site, and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6, 7, 13, 19, and 20 all encode the same isoform (3).
      Source sequence(s)
      BC041695, CA439866, DA443888
      Consensus CDS
      CCDS94152.1
      UniProtKB/TrEMBL
      C9JIW8, Q86U76
      Related
      ENSP00000416088.2, ENST00000412947.6
      Conserved Domains (4) summary
      COG5048
      Location:139 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 55
      KRAB; KRAB box
      pfam13465
      Location:318 → 343
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001278292.2 → NP_001265221.1  zinc finger protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks the exon containing the translation start site and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6, 7, 13, 19, and 20 all encode the same isoform (3).
      Source sequence(s)
      BC041695, CA439866, DA623743
      Consensus CDS
      CCDS94152.1
      UniProtKB/TrEMBL
      C9JIW8, Q86U76
      Conserved Domains (4) summary
      COG5048
      Location:139 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 55
      KRAB; KRAB box
      pfam13465
      Location:318 → 343
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001318135.2 → NP_001305064.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
      Source sequence(s)
      BC011887, BC025265, CA439866, DC347416
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001318136.2 → NP_001305065.1  zinc finger protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two exons in its 5' UTR, contains an alternate internal segment, and uses an alternate start codon, compared to variant 3. The encoded isoform (4) has a longer and distinct N-terminus, compared to isoform 2. Variants 9, 11, and 21 all encode the same isoform (4).
      Source sequence(s)
      AK091984, BC013603, CA439866, CB988353
      UniProtKB/Swiss-Prot
      P17036
      UniProtKB/TrEMBL
      B3KRP4
      Related
      ENST00000487620.1
      Conserved Domains (4) summary
      COG5048
      Location:182 → 360
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:57 → 98
      KRAB; KRAB box
      pfam13465
      Location:361 → 386
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001318137.2 → NP_001305066.1  zinc finger protein 3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) has multiple differences in the UTRs and coding region, one of which results in the use of a downstream in-frame start codon, compared to variant 3. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC093619, AF193057, AK000223, BC011887, CB129643, DC347416
      UniProtKB/Swiss-Prot
      P17036
      Conserved Domains (2) summary
      smart00349
      Location:15 → 55
      KRAB; krueppel associated box
      pfam01352
      Location:15 → 54
      KRAB; KRAB box

    9. NM_001362775.2 → NP_001349704.1  zinc finger protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 9 and 21, encodes isoform 4.
      Source sequence(s)
      AK091984, BC013603, CA439866, CB988353, DA955742
      Conserved Domains (4) summary
      COG5048
      Location:182 → 360
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:57 → 98
      KRAB; KRAB box
      pfam13465
      Location:361 → 386
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001362776.2 → NP_001349705.1  zinc finger protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC073842, BC041695, CA439866, HY096067
      Conserved Domains (4) summary
      COG5048
      Location:180 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:55 → 96
      KRAB; KRAB box
      pfam13465
      Location:359 → 384
      zf-H2C2_2; Zinc-finger double domain

    11. NM_001362777.2 → NP_001349706.1  zinc finger protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 6, 7, 19, and 20, encodes isoform 3.
      Source sequence(s)
      BC041695, BP194298, CA439866, DA623743, DA961971
      Consensus CDS
      CCDS94152.1
      UniProtKB/TrEMBL
      C9JIW8, Q86U76
      Conserved Domains (4) summary
      COG5048
      Location:139 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 55
      KRAB; KRAB box
      pfam13465
      Location:318 → 343
      zf-H2C2_2; Zinc-finger double domain

    12. NM_001371210.1 → NP_001358139.1  zinc finger protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS43618.1
      Conserved Domains (1) summary
      pfam01352
      Location:50 → 91
      KRAB; KRAB box

    13. NM_001371211.1 → NP_001358140.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 2-5, 8, and 16-18, encodes isoform 2.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    14. NM_001371212.1 → NP_001358141.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 2-5, 8, 15, 17, and 18, encodes isoform 2.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    15. NM_001371213.1 → NP_001358142.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 2-5, 8, 15, 16, and 18, encodes isoform 2.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    16. NM_001371214.1 → NP_001358143.1  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 2-5, 8, and 15-17, encodes isoform 2.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    17. NM_001371215.1 → NP_001358144.1  zinc finger protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 6, 7, 13, and 20, encodes isoform 3.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS94152.1
      UniProtKB/TrEMBL
      C9JIW8, Q86U76
      Conserved Domains (4) summary
      COG5048
      Location:139 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 55
      KRAB; KRAB box
      pfam13465
      Location:318 → 343
      zf-H2C2_2; Zinc-finger double domain

    18. NM_001371216.1 → NP_001358145.1  zinc finger protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 6, 7, 13, and 19, encodes isoform 3.
      Source sequence(s)
      AC073842, AC093619
      Consensus CDS
      CCDS94152.1
      UniProtKB/TrEMBL
      C9JIW8, Q86U76
      Conserved Domains (4) summary
      COG5048
      Location:139 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 55
      KRAB; KRAB box
      pfam13465
      Location:318 → 343
      zf-H2C2_2; Zinc-finger double domain

    19. NM_001371217.1 → NP_001358146.1  zinc finger protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 9 and 11, encodes isoform 4.
      Source sequence(s)
      AC073842, AC093619
      Conserved Domains (4) summary
      COG5048
      Location:182 → 360
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:57 → 98
      KRAB; KRAB box
      pfam13465
      Location:361 → 386
      zf-H2C2_2; Zinc-finger double domain

    20. NM_001371218.1 → NP_001358147.1  zinc finger protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC073842, AC093619
      Conserved Domains (3) summary
      COG5048
      Location:96 → 274
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:207 → 227
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:275 → 300
      zf-H2C2_2; Zinc-finger double domain

    21. NM_017715.4 → NP_060185.2  zinc finger protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2. Variants 1 and 14 both encode the same isoform (1).
      Source sequence(s)
      AC093619, AF217988, AK000223
      Consensus CDS
      CCDS43618.1
      UniProtKB/Swiss-Prot
      P17036
      Related
      ENSP00000399951.2, ENST00000413658.6
      Conserved Domains (1) summary
      pfam01352
      Location:50 → 91
      KRAB; KRAB box

    22. NM_032924.5 → NP_116313.3  zinc finger protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
      Source sequence(s)
      BC013603, CA439866, DC384519
      Consensus CDS
      CCDS43619.1
      UniProtKB/Swiss-Prot
      D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
      Related
      ENSP00000299667.4, ENST00000299667.9
      Conserved Domains (4) summary
      COG5048
      Location:175 → 353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:50 → 91
      KRAB; KRAB box
      pfam13465
      Location:354 → 379
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100063837..100082577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420802.1 → XP_047276758.1  zinc finger protein 3 isoform X3

    2. XM_024446921.2 → XP_024302689.1  zinc finger protein 3 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:180 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:55 → 96
      KRAB; KRAB box
      pfam13465
      Location:359 → 384
      zf-H2C2_2; Zinc-finger double domain

    3. XM_024446920.2 → XP_024302688.1  zinc finger protein 3 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:180 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:55 → 96
      KRAB; KRAB box
      pfam13465
      Location:359 → 384
      zf-H2C2_2; Zinc-finger double domain

    4. XM_024446925.2 → XP_024302693.1  zinc finger protein 3 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:144 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:19 → 60
      KRAB; KRAB box
      pfam13465
      Location:323 → 348
      zf-H2C2_2; Zinc-finger double domain

    5. XM_024446919.2 → XP_024302687.1  zinc finger protein 3 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:180 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:55 → 96
      KRAB; KRAB box
      pfam13465
      Location:359 → 384
      zf-H2C2_2; Zinc-finger double domain

    6. XM_024446927.2 → XP_024302695.1  zinc finger protein 3 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:144 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:19 → 60
      KRAB; KRAB box
      pfam13465
      Location:323 → 348
      zf-H2C2_2; Zinc-finger double domain

    7. XM_024446928.2 → XP_024302696.1  zinc finger protein 3 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:144 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:19 → 60
      KRAB; KRAB box
      pfam13465
      Location:323 → 348
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101303346..101322424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358947.1 → XP_054214922.1  zinc finger protein 3 isoform X3

    2. XM_054358943.1 → XP_054214918.1  zinc finger protein 3 isoform X1

    3. XM_054358942.1 → XP_054214917.1  zinc finger protein 3 isoform X1

    4. XM_054358944.1 → XP_054214919.1  zinc finger protein 3 isoform X2

    5. XM_054358941.1 → XP_054214916.1  zinc finger protein 3 isoform X1

    6. XM_054358946.1 → XP_054214921.1  zinc finger protein 3 isoform X2

    7. XM_054358945.1 → XP_054214920.1  zinc finger protein 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17036.3 GenPept UniProtKB/Swiss-Prot:P17036

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