HSL7 protein arginine N-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HSL7
Official Full Name: protein arginine N-methyltransferase
Primary source: SGD:S000000337
Locus tag: YBR133C
See related: AllianceGenome:SGD:S000000337; FungiDB:YBR133C; VEuPathDB:YBR133C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein-arginine omega-N monomethyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Involved in G2/M transition of mitotic cell cycle; protein catabolic process; and regulation of cell cycle. Located in cellular bud neck septin collar; cellular bud neck septin ring; and outer plaque of spindle pole body. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HSL7 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (501804..504287, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsl7 has a repressive role in transcription. Hsl7 is responsible for in vivo symmetric dimethylation of histone H4 arginine 3 in a transcriptionally repressed state.
Title: Yeast symmetric arginine methyltransferase Hsl7 has a repressive role in transcription.
Hsl7p interaction with Hsl1p is not needed for degradation of septin-Swe1p fusion protein.
Title: Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering.
Hsl7 can display type II type II protein arginine methyltransferase activity.
Title: Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone H2AQ104 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K37 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N monomethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck septin collar	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck septin ring	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in outer plaque of spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein arginine N-methyltransferase

NP_009691.1

EC 2.1.1.320

Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; responsible for symmetric dimethylation of histone H4 on Arg3; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

501804..504287 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178481.1 → NP_009691.1 TPA: protein arginine N-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009691.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2NP39, D6VQD0, P38274

UniProtKB/TrEMBL

B3LN23, G2W9D7, N1P6Q3

Conserved Domains (3) summary

pfam05185
Location:316 → 493

PRMT5; PRMT5 arginine-N-methyltransferase

pfam17285
Location:38 → 308

PRMT5_TIM; PRMT5 TIM barrel domain

pfam17286
Location:496 → 690

PRMT5_C; PRMT5 oligomerization domain