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    RTC2 cationic amino acid transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTC2
    Official Full Name
    cationic amino acid transporter
    Primary source
    SGD:S000000351
    Locus tag
    YBR147W
    See related
    AllianceGenome:SGD:S000000351; FungiDB:YBR147W; VEuPathDB:YBR147W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RRT11; YPQ3
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (536575..537465)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase ADH5 Neighboring gene mitochondrial 37S ribosomal protein MRPS9 Neighboring gene Ysw1p Neighboring gene D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitrogen coordinated import and export of arginine across the yeast vacuolar membrane. Cools M, et al. PLoS Genet, 2020 Aug. PMID 32776922, Free PMC Article
    2. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Manabe K, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26928127
    3. mRNA with Mammalian Codon Bias Accumulates in Yeast Mutants with Constitutive Stress Granules. Kozlova NV, et al. Int J Mol Sci, 2020 Feb 12. PMID 32059599, Free PMC Article
    4. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article
    5. A role for phosphatidic acid in the formation of "supersized" lipid droplets. Fei W, et al. PLoS Genet, 2011 Jul. PMID 21829381, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables basic amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cationic amino acid transporter
    NP_009705.1
    • Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      536575..537465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178495.1 → NP_009705.1  TPA: cationic amino acid transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQE2, P38279
      UniProtKB/TrEMBL
      B3LN11, N1P9H8
      Conserved Domains (1) summary
      pfam04193
      Location:13 → 73
      PQ-loop; PQ loop repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38279.1

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